Results 201 to 210 of about 155,237 (261)

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

The role of inflammation in the immune evasion of KRas. [PDF]

Front Immunol
Homan EJ, Bremel RD.
europepmc   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Structure-Guided Design of an Interface-Derived Inhibitor Peptide Against Spodoptera frugiperda Digestive Trypsins. [PDF]

Arch Insect Biochem Physiol
Severiche-Castro J, Valerio MF, Oliveira MGA.   +2 more
europepmc   +1 more source

Trypsin inhibitors demonstrate antioxidant activities, inhibit A549 cell proliferation, and increase activities of reactive oxygen species scavenging enzymes.

Indian J Pharmacol, 2017
Shamsi TN, Parveen R, Fatima S.
europepmc   +1 more source

Chromosome-Scale Atlas of <i>Ixodes scapularis</i> Serine Protease Inhibitors. [PDF]

Genes (Basel)
Gaithuma ASK, Nguyen TT, Mulenga A.
europepmc   +1 more source

Potential of Quantitative α-Amylase or Trypsin Inhibition by Refined and Whole Wheat and Einkorn Using High-Performance Thin-Layer Chromatography-NanoGIT versus Conventional Spectrophotometry. [PDF]

J Agric Food Chem
Müller I, Scheibelhut I, Morlock GE.
europepmc   +1 more source

Biochemical Characterization of a Kunitz-Type Protease Inhibitor From Mimosa regnellii and Its Effects on Melanoma Cell Viability and Angiogenesis. [PDF]

Chem Biodivers
Rabêlo LMA, Cardoso PHO, Nobre LTDB, Dos Santos PIM, Lucena SV, Serquiz RP, Bemquerer MP, Rocha HAO, Nader HB, Dos Santos EA, de Oliveira AS, Frihling BEF, Migliolo L.   +12 more
europepmc   +1 more source