Results 181 to 190 of about 16,690 (208)

Effects of pyrazole on rat liver tryptophan oxygenase

Life Sciences, 1976
Abstract The effects of pyrazole administration on rat liver tryptophan oxygenase have been studied both under basal conditions and after induction by cortisol or activation by tryptophan. Pyrazole administration is followed by a decrease of the basal holoenzyme and total enzyme activities.
H, Rouach, C, Ribière, J, Nordmann, R, Nordmann   +3 more
openaire   +2 more sources

11–Deoxycortisol Induces Hepatic Tryptophan Oxygenase in Rats

Acta Pharmacologica et Toxicologica, 1985
Abstract: 11–Deoxycortisol (cortexolone) has previously been used as a glucocorticoid antagonist in vitro and in adrenalectomized rats. Antiglucocorticoid properties of 11–deoxycortisol in intact rats were examined by studying the effect of 11–deoxycortisol on the induction of hepatic tryptophan oxygenase (TO) by corticosterone.
H, Gjerde, G, Gadeholt, H, Olsen, J, Mørland, N, Norman   +4 more
openaire   +2 more sources

Purification of tryptophan oxygenase and its interaction with cadmium

Biochemical and Biophysical Research Communications, 1973
Abstract Purification of tryptophan oxygenase (L-tryptophan oxidoreductase EC 1.13.1.12) from Pseudomonos acidovorans is described. When chromatographed on Sephadex G-200 or on DEAE Sephadex A-50, the enzyme was eluted in two distinct bands. Over the concentration range 10−6 – 10−4 M, cadmium stimulated the activity of the enzyme but inhibited ...
E M, Diamond, A, Jedeikin, J E, Kench
openaire   +2 more sources

Tryptophan, Oxygenase, and Sleep

1996
In May 1974, or about 21 years ago, when the first International Meeting of ISTRY was held in this beautiful city of Padova, I had the great pleasure of making personal acquaintance with Prof. Luigi Musajo, whom I had heard about so much while I was in Japan.
openaire   +1 more source

A specific and sensitive fluorometric assay for tryptophan oxygenase

Archives of Biochemistry and Biophysics, 1973
Abstract A spectrophotofluorometric assay was used to measure tryptophan oxygenase activity in several species. The fluorescent assay depends on the conversion of the product of the reaction, N-formyl- l -kynurenine, to anthranilate by means of the coupling enzymes kynurenine formamidase and kynureninase.
D A, Casciano, F H, Gaertner
openaire   +2 more sources

Activation of liver tryptophan oxygenase by hydrocortisone, hematin and tryptophan in streptozotocin-diabetic rats

Life Sciences, 1984
This study compared changes in liver tryptophan oxygenase (TPO) activity in response to hydrocortisone, hematin and tryptophan administration to non-diabetic and diabetic (streptozotocin) rats. Hydrocortisone caused similar increases in apoenzyme (inactive), holoenzyme (heme-saturated) and total (holoenzyme + apoenzyme) TPO activities in non-diabetic ...
E M, Sadler, M, Weiner, G G, Buterbaugh
openaire   +2 more sources

Photoactivation of pseudomonad l-tryptophan oxygenase by electron ejection from its substrate, l-tryptophan

Archives of Biochemistry and Biophysics, 1973
Abstract Chemically oxidized, catalytically inactive, pseudomonad l -tryptophan-2,3-dioxygenase (EC 1.13.1.12) can be photoactivated aerobically as well as anaerobically by light of wavelength less than 360 nm. The substrate, l -tryptophan, must be present for photoactivation to proceed.
F O, Brady, P, Feigelson
openaire   +2 more sources

Ethanol increases rat liver tryptophan oxygenase: Evidence for corticosterone mediation

Alcohol, 1985
Acute administration of ethanol (4.0 g/kg) intragastrically or intraperitoneally induced rat liver tryptophan oxygenase (TO) activity 3-4 fold 4-5 hr later. Ethanol administration increased the concentration of plasma free tryptophan and free fatty acids.
J, Mørland, L, Stowell, H, Gjerde
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The effect of ethyl alcohol on rat liver tryptophan oxygenase

Life Sciences, 1972
Abstract The activity of liver tryptophan oxygenase was determined in rats administered intoxicating dose of ethanol. Following intraperitoneal injection of ethanol there was a rise in the enzyme activity reaching levels considerably above those of the control animals.
V M, Sardesai, H S, Provido
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Ethanol-induced increase in liver tryptophan oxygenase activity in the starved rat: Evidence against tryptophan mediation

Biochemical Pharmacology, 1984
A single oral dose of ethanol (4.0 g/kg) increased the activity of liver tryptophan oxygenase in starved male rats. The peak increase of 340% for the total activity and 400% for the holoenzyme activity occurred 6 hr after ethanol administration.
L, Stowell, J, Mørland
openaire   +2 more sources