Results 191 to 200 of about 79,060 (245)

The full-length TSH receptor is stabilized by TSH ligand

Journal of Molecular Graphics and Modelling, 2023
The receptor for thyroid stimulating hormone (TSHR), a GPCR, is the primary antigen in autoimmune hyperthyroidism (Graves' disease) caused by stimulating TSHR antibodies. While we have previously published a full length model of the TSHR, including its leucine rich domain (LRD), linker region (LR) and transmembrane domain (TMD), to date, only a partial
Mihaly Mezei, Rauf Latif, Terry F. Davies   +2 more
openaire   +2 more sources

IMMUNOPRECIPITATION OF TSH‐TSH RECEPTOR COMPLEXES

Clinical Endocrinology, 1985
SUMMARYThe ability of Graves' sera to interact with the TSH receptor crosslinked to a 125I‐labelled photoactive derivative of TSH has been investigated. Crosslinked complexes were prepared using non‐purified detergent solubilized human thyroid and guinea pig fat TSH receptors. Affinity purified porcine TSH receptor preparations were also used.
A B, Parkes, Y, Kajita, P R, Buckland, R D, Howells, C R, Rickards, F M, Creagh, B, Rees Smith   +6 more
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TSH adenomas

Pituitary, 2006
Thyrotropin (TSH) adenomas are uncommon tumors of the anterior pituitary. Clinically, they may present with hyperthyroidism, hypothyroidism, hypopituitarism, or visual loss. Proper diagnosis requires appropriate neuroendocrine evaluation. Although transsphenoidal surgery remains the first-line treatment, adjuvant medical therapy is frequently required ...
Edward R, Laws, Mary Lee, Vance, John A, Jane   +2 more
openaire   +2 more sources

A Rare Cause of Discordant TSH: MACRO-TSH

Acta Endocrinologica (Bucharest), 2015
Background. When the laboratory results are not compatible with the clinical features of the patient, the presence of assay interference should be considered.
Yalcin, MEHMET MUHİTTİN, GÜLBAHAR, ÖZLEM, Altinova, ALEV, Akturk, MÜJDE YAŞIM, Ayvaz, Goksun, Ozkan, Cigdem, Arslan, Metin, Toruner, FÜSUN SAADET   +7 more
openaire   +3 more sources

Resistance to thyrotropin (TSH) in three families is not associated with mutations in the TSH receptor or TSH.

The Journal of clinical endocrinology and metabolism, 1997
info:eu-repo/semantics ...
J. Xie, S. Pannain, J. Pohlenz, R. E. Weiss, K. Moltz, M. Morlot, C. Asteria, L. Persani, P. Beck Peccoz, J. Parma, G. Vassart, S. Refetoff   +11 more
openaire   +4 more sources

The interference of anti-TSH autoantibody on clinical TSH detection

Frontiers in Endocrinology
ObjectiveIt is well known that macro-thyroid-stimulating hormone (macro-TSH) could interfere with the detection of TSH. The anti-TSH autoantibody is an essential component of macro-TSH. However, the epidemiological characteristics and the clinical interference of the anti-TSH autoantibody are unclear.MethodsIn this study, the radioimmunoprecipitation ...
Chunjia Kou, Haiqing Zhang, Ni Jiajia
exaly   +4 more sources

Inhibition of endogenous TSH in rats by antiserum to bovine TSH

Experientia, 1962
Gli autori hanno ottenuto in conigli un siero anti-TSH usando come antigene ormone bovino. Questo siero inibisce il TSH endogeno di ratti nutriti con dieta di Remington e trattati con tiouracile, impedendo cosi la formazione della iperplasia tiroidea.
L, BASCHIERI, M, NEGRI, F, DE LUCA, L, SERENO, L, CRAMAROSSA   +4 more
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Recombinant TSH-Receptor for Determination of TSH-Receptor-Antibodies

Experimental and Clinical Endocrinology & Diabetes, 2009
We have expressed the complete coding sequence of the human TSH-R in eucaryotic cells. Limiting dilution enabled us to select two clones, JP09 and JP26, which have formed the basis of binding and bioassays respectively, for TSH-R antibodies. Results obtained in the binding assay correlated well with those obtained in the TRAK (Henning Berlin) assay ...
Ludgate, Marian, Costagliola, Sabine, Danguy, Dominique, Perret, Jason, Vassart, Gilbert   +4 more
openaire   +3 more sources

TSH CROSSLINKS TO THE TSH RECEPTOR THROUGH THE β SUBUNIT

Endocrinology, 1985
TSH binds specifically to the TSH receptor present on the surface of thyroid follicular cells and consequently activates adenylate cyclase. It was not known, however, which of the two subunits of the TSH bound to the receptor. By covalently crosslinking TSH to its receptor and characterizing the product with antisera specific for either the alpha or ...
P R, Buckland, T W, Strickland, J G, Pierce, B R, Smith   +3 more
openaire   +2 more sources

Choosing Wisely^®: To TSH or not to TSH?

Journal of Hospital Medicine, 2022
Moises Auron, John Bulger
openaire   +2 more sources