Results 151 to 160 of about 62,282 (304)

TETRAHEURÍSTICA SISTÉMICA (THS) PARA EL TSP SYSTEMIC TETRAHEURISTIC FOR THE TSP

Ingeniare: Revista Chilena de Ingeniería, 2010
Este artículo presenta un novedoso método, basado en elementos del pensamiento sistémico, para solucionar instancias del problema del vendedor viajero (TSP), el cual es comparado en términos de eficacia y eficiencia con "nearest neighbour", "cheapest ...
Jorge Iván Pérez Rave, Gloria Patricia Jaramillo Álvarez, Carlos Mario Parra Mesa, Luis Fernando Moreno Velásquez   +3 more
doaj  

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

RF SYNTHESIZER WITH DIRECT DIGITAL SYNTHESIZ

Приборы и методы измерений, 2015
A synthesizer of frequencies with direct digital synthesis and a frequency multiplier on PLL are developed. Phase noises of an output signal of the synthesizer, noise of a loop of PLL, level of collateral radiations on outputs of the digital synthesizer (
V. V. Murav’iov, S. A. Korenevsky, N. M. Naumovich, A. A. Stanul   +3 more
doaj  

Triple‐Mutated HSV‐1 Expressing Soluble B7‐1 Plus CTLA‐4 Blockade Suppresses Lymph Node Metastasis in Tongue Cancer

Cancer Science, EarlyView.
In murine tongue cancer models, T‐mB7‐1, a triple‐mutated oncolytic herpes simplex virus type 1 (HSV‐1) engineered to express soluble B7‐1, suppresses cervical lymph node metastasis and improves survival, addressing a major prognostic determinant in oral squamous cell carcinoma (OSCC).
Akinari Sugauchi, Toshihiro Uchihashi, Hirotaka Ito, Miwako Iwai, Yuzuri Tsurumaki Sato, Kyoko Kurioka, Sena Zeynep Usta, Minoru Tanaka, Mikihiko Kogo, Susumu Tanaka, Hiroshi Fukuhara, Tomoki Todo   +11 more
wiley   +1 more source

Noisy Graph Patterns via Ordered Matrices

Computer Graphics Forum, EarlyView.
Abstract The high‐level structure of a graph is a crucial ingredient for the analysis and visualization of relational data. However, discovering the salient graph patterns that form this structure is notoriously difficult for two reasons. (1) Finding important patterns, such as cliques and bicliques, is computationally hard.
J. Wulms, W. Meulemans, B. Speckmann
wiley   +1 more source

Single Line Drawing Generation via Semantics‐Driven Optimization

Computer Graphics Forum, EarlyView.
We present a method for automatically generating single‐line drawings in vector format, guided by a text prompt or an input image. Our approach leverages score distillation sampling to optimize the parameters of a uniform rational B‐spline (URBS) curve, ensuring that the drawing consists of a single continuous stroke by design.
Tanguy Magne, Alexandre Binninger, Ruben Wiersma, Olga Sorkine‐Hornung   +3 more
wiley   +1 more source

A multi-site qualitative evaluation of the accredited Thinking Skills Programme (TSP)

MOJ commissioned the University of Derby to conduct a qualitative evaluation of Thinking Skills Programme (TSP) delivered in prisons. TSP is a HMPPS accredited offending behaviour programme, which is designed for adult men and women who are assessed as ...
Penford, E., Blagden, N., Mason, J., Delliere-Moor, P., Vinter, L.P.   +4 more
core  

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source