Results 51 to 60 of about 182,746 (274)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Non-Linearities of Complicated Lever Mechanisms of Electric and Hydraulic Drives

Наука и техника, 2014
The paper determines conversion coefficients for mechanical transmissions of electric and hydraulic drives which are used in special equipment. Nonlinearities of conversion coefficients  for mechanical transmissions have been revealed in the paper ...
A. G. Strizhnev, A. N. Rusakovich
doaj  

Restricted Dynamic Programming Heuristic for Precedence Constrained Bottleneck Generalized TSP [PDF]

, 2015
We develop a restricted dynamical programming heuristic for a complicated traveling salesman problem: a) cities are grouped into clusters, resp.
Salii, Y.
core  

The Traveling Salesman Problem: Low-Dimensionality Implies a Polynomial Time Approximation Scheme

, 2015
The Traveling Salesman Problem (TSP) is among the most famous NP-hard optimization problems. We design for this problem a randomized polynomial-time algorithm that computes a (1+eps)-approximation to the optimal tour, for any fixed eps>0, in TSP ...
Abraham I., Arora S., Assouad P., Bartal Y., Bartal Y., Bartal Y., Chan T-H. H., Chan T-H. H., Czumaj A., Czumaj A., Fakcharoenphol J., Gao J., Gottlieb L.-A., Gottlieb L.-A., Gottlieb L.-A., Gupta A., J. S., Lampis M., Lee-Ad Gottlieb, Rao S. B., Robert Krauthgamer, Talwar K., Yair Bartal   +22 more
core   +1 more source

An ETH-Tight Exact Algorithm for Euclidean TSP [PDF]

, 2018
We study exact algorithms for {\sc Euclidean TSP} in $\mathbb{R}^d$. In the early 1990s algorithms with $n^{O(\sqrt{n})}$ running time were presented for the planar case, and some years later an algorithm with $n^{O(n^{1-1/d})}$ running time was ...
Bodlaender, Hans L., de Berg, Mark, Kisfaludi-Bak, Sándor, Kolay, Sudeshna, Thorup, Mikkel   +4 more
core   +4 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Positioning control of reference units of automatic raising and leveling system of support platform

Informatika, 2018
The questions of positioning control of reference units of automatic raising and leveling system of support platform were considered in the article. The list of functional elements which are needed for analyzing the hydraulic reference units behavior in ...
A. G. Strizhnev, A. A. Shykhau
doaj  

A green and efficient process for the synthesis of Benzothiazinones using Phosphate fertilizers MAP, DAP and TSP as heterogeneous catalysts

Journal of the Turkish Chemical Society, Section A: Chemistry, 2019
The aim of this work is to prove the efficiency of the Phosphate fertilizers mono-ammonium phosphate (MAP), di-ammonium phosphate (DAP) and triple-super phosphate (TSP) as a “green” heterogeneous catalysts for the synthesis of 2-aryl-2H-benzo[b][1,4 ...
IMANE BAHAMMOU, BADR MALEK, TOURYA GHAILANE , RACHIDA GHAILANE, SAID BOUKHRIS, Abdelaziz SOUIZI   +5 more
doaj   +1 more source

Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer [PDF]

, 2016
The aim of the present study was to compare the clinical utility of two measures of the inflammatory cell infiltrate - a H&E-based assessment of the generalised inflammatory cell infiltrate (the Klintrup-Mäkinen (KM) grade), and an ...
Edwards, J., Horgan, P. G., McMillan, D. C., Park, J. H., Roxburgh, Campbell S.D.   +4 more
core   +1 more source

Bidirectional Photoswitching of a Tailored Azobenzene with Red and Far‐Red Light Involving Triplet Sensitization in an Aqueous System

Advanced Science, EarlyView.
The action spectrum of a tailored azobenzene is shifted toward bio‐optical window through the chemical modification of its singlet and triplet energy levels. Consequently, the bidirectional photo‐switching of azobenzene in physiological conditions is achieved when excited by red and far‐red light, which offers greater tissue penetration.
Mila Miroshnichenko, Helen Hölzel, Edvinas Orentas, Karolis Kazlauskas, Pedro Ferreira, Fabienne Dumoulin, Carles Alcaide, Miquel Solà, Roger Bresolí‐Obach, Santi Nonell, Pankaj Bharmoria, Kasper Moth‐Poulsen   +11 more
wiley   +1 more source