Results 191 to 200 of about 214,058 (283)

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

Cancer Science, EarlyView.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei, Yasutaka Yamada, Takaaki Tamura, Masahiro Sugiura, Xue Zhao, Meng Ni, Adilan Aierken, Tomokazu Sazuka, Yusuke Imamura, Shinichi Sakamoto   +9 more
wiley   +1 more source

Efficacy of Nivolumab in Chemotherapy-Resistant Mesothelioma of the Tunica Vaginalis Testis: A Case Report. [PDF]

Cancer Rep (Hoboken)
Koyanagi H, Kawahara T, Inagawa N, Shiga M, Sakurai H, Yamaguchi A, Tanuma K, Nitta S, Kojo K, Shiga M, Nagumo Y, Ikeda A, Kandori S, Hoshi A, Negoro H, Kawai H, Matsubara D, Nishiyama H.   +17 more
europepmc   +1 more source

Real‐World Safety and Efficacy of Pola‐R‐CHP in Previously Untreated DLBCL: POLASTAR Interim Analysis of 500 Patients

Cancer Science, EarlyView.
In this analysis of a diverse cohort of 500 patients with previously untreated DLBCL in a real‐world clinical setting, Pola‐R‐CHP demonstrated high response rates at end‐of‐treatment, which were consistent among the overall population, in patients > 80 years and regardless of International Prognostic Index status and cell of origin subtypes.
Takahiro Kumode, Hitomi Sawa, Kohta Miyawaki, Atsushi Satake, Nobuhiro Kanemura, Ritsuro Suzuki, Yuki Fujiwara, Yasuhiro Nagate, Shuichi Ota, Takahiro Fujino, Hideki Goto, Noriko Fukuhara, Mamiko Sakata‐Yanagimoto, Koji Izutsu, Momoko Nishikori, Hirohiko Shibayama, Daisuke Ennishi, Takayuki Shimose, Mai Asai, Itaru Matsumura, Koichi Akashi, Koji Kato   +21 more
wiley   +1 more source

Biphasic growth and subsequent spontaneous regression of posterior fossa meningioma with progressive calcification: illustrative case. [PDF]

J Neurosurg Case Lessons
Takahashi T, Yanaka K, Aiyama H, Maruyama S, Takahashi N, Marushima A, Ishikawa E.   +6 more
europepmc   +1 more source

Nicotinic Acid Restriction Enhances the Therapeutic Benefit of NAMPT Inhibition in Small‐Cell Lung Cancer Models

Cancer Science, EarlyView.
Dietary NA restriction converts the effect of NAMPT inhibition from cytostatic to cytotoxic in SCLC in vivo. ABSTRACT Small‐cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. We previously showed that nicotinic acid riboside (NAR) sustains NAD biosynthesis in vivo and compensates for NAMPT inhibition in SCLC models ...
Kyoji Tsurumi, Miyuki Nomura, Mai Ouchi, Shigehiro Yagishita, Naohiko Kikuchi, Taku Sato, Mami Morita, Yoji Yamashita, Kayoko Hayashi, Tomoyoshi Soga, Akinobu Hamada, Tatsuro Fukuhara, Nobuhiro Tanuma   +12 more
wiley   +1 more source

Multimorbidity Among Patients Receiving Home Care in Japan: Prevalence, Levels, and Association With Emergency Home Visits. [PDF]

J Gen Fam Med
Nakayama G, Masumoto S, Sun Y, Ishii M, Nin S, Inaba T, Kajikawa N, Hamada S, Kimura N, Hamano J.   +9 more
europepmc   +1 more source

Targeted Photo‐Induced Elimination of Tumor‐Associated Macrophages Suppresses Cancer Progression in a Murine Model

Cancer Science, EarlyView.
This study demonstrates the selective depletion of tumor‐associated macrophages (TAMs) by targeting CSF1R through near‐infrared photoimmunotherapy (NIR‐PIT). Using a combination of anti‐CSF1R Fab‐IR700 conjugates and localized light irradiation, we achieved tumor suppression and durable antitumor immunity without systemic toxicity.
Kohei Nakajima, Tomomi Uchiyama, Kazuki Funayama, Yuto Goto, Akari Mukaimine, Naoya Ieda, Mikako Ogawa   +6 more
wiley   +1 more source

Bilateral intradiploic dermoid cysts with unilateral rupture causing hearing loss: illustrative case. [PDF]

J Neurosurg Case Lessons
Maruyama S, Yanaka K, Saura M, Takahashi T, Aiyama H, Takahashi N, Sakamoto N, Marushima A, Ishikawa E.   +8 more
europepmc   +1 more source

Meteorological observations on Mount Tsukuba

Journal of the Meteorological Society of Japan. Ser. I, 1906
openaire   +2 more sources