Results 51 to 60 of about 363,616 (286)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
DronesRobust unmanned aerial vehicle (UAV) detection in real low-altitude anti-UAV scenarios remains challenging due to motion blur, extreme illumination, cluttered backgrounds, and tiny target sizes.
Ruizhi Zhang +5 more
doaj +1 more source
Enhanced Data Return from Lunar Farside using RF-Optical TT and C [PDF]
, 2008 Science return and high bandwidth communications are key issues to support the foreseen endeavours on spaceflights to the Moon and beyond. For a given mass, power consumption and volume, laser communications can offer an increase in TM bandwidth over ...
Giggenbach, Dirk +5 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Effects of body size and load carriage on lower-extremity biomechanical responses in healthy women
BMC Musculoskeletal Disorders, 2021 Background Musculoskeletal injuries, such as stress fractures, are the single most important medical impediment to military readiness in the U.S. Army.
Ginu Unnikrishnan +6 more
doaj +1 more source
stigLD: Stigmergic Coordination in Linked Systems
Mathematics, 2022 While current Semantic Web technologies are well-suited for data publication and integration, the design and deployment of dynamic, autonomous and long-lived multi-agent systems (MAS) on the Web is still in its infancy. Following the vision of hypermedia
René Schubotz +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
TuLiPA : a syntax-semantics parsing environment for mildly context-sensitive formalisms [PDF]
, 2008 In this paper we present a parsing architecture that allows processing of different mildly context-sensitive formalisms, in particular Tree-Adjoining Grammar (TAG), Multi-Component Tree-Adjoining Grammar with Tree Tuples (TT-MCTAG) and simple Range ...
Dellert, Johannes +9 more
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