Results 111 to 120 of about 103,435 (271)

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia–Reperfusion Injury

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang   +5 more
wiley   +1 more source

RETRACTED: Improvement in Collision Avoidance in Cut-In Maneuvers Using Time-to-Collision Metrics

open access: yesSmart Cities
This paper proposes a new strategy for a collision avoidance system leveraging time-to-collision (TTC) metrics for handling cut-in scenarios, which are particularly challenging for autonomous vehicles (AVs).
Jamal Raiyn
doaj   +1 more source

Modular Polymers With Tuneable Charge and Amphiphilicity for Effective Antimicrobial Photodynamic Therapy

open access: yesMacromolecular Rapid Communications, EarlyView.
A modular dual‐strategy platform combining free radical copolymerisation and post‐polymerisation modification yields a library of ruthenium‐functionalised polymers for antimicrobial photodynamic therapy. Tuneable composition and net charge govern activity against multidrug‐resistant Pseudomonas aeruginosa biofilms and Staphylococcus aureus under ...
Ali Balasini   +8 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

open access: yesNeuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi   +5 more
wiley   +1 more source

Saussurea × media (Asteraceae), a new natural hybrid between S. parviflora and S. controversa

open access: yesNordic Journal of Botany, EarlyView.
Saussurea × media Yusupovsky and E.Pjak (Asteraceae), a new nothospecies from the Altai‐Sayan Mountains, is described and illustrated. In this study, we sequenced the internal transcribed spacer of nuclear ribosomal DNA and the chloroplast intergenic spacers rsp16‐trnQ and ycf4‐cemA to verify the hypothesis of hybridization between Saussurea parviflora
Daniil V. Yusupovsky, Elizaveta A. Pyak
wiley   +1 more source

The shared benefits of fallen fruits: A novel mechanism stabilizing a nursery pollination mutualism between Sambucus and kateretid beetles

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Understanding how cooperative interactions remain stable matters for biodiversity because many plants rely on specialist insects that can also impose reproductive costs. We studied the interaction between Sambucus sieboldiana and seed‐consuming Heterhelus beetles through detailed field observations and pollination experiments.
Suzu Kawashima   +3 more
wiley   +1 more source

The potential global distribution of Drosophila suzukii, including consideration of irrigation and Australian host cropping areas

open access: yesPest Management Science, EarlyView.
This CLIMEX model of Drosophila suzukii fits the global distribution very well and includes irrigation effects. It indicates that D. suzukii could threaten all Australian berry and cherry production areas if introduced. Abstract BACKGROUND Spotted wing drosophila, Drosophila suzukii (Matsumura), is a major fruit fly pest of cherries and berries across ...
Jessica Mae Kriticos   +2 more
wiley   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

open access: yesResponsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang   +6 more
wiley   +1 more source

A Biomimetic Breast Tumor‐On‐Chip Platform Reveals Mesenchymal Marker Upregulation Following Gold Nanorod Photothermal Therapy

open access: yesSmall, EarlyView.
A biomimetic microfluidic tumor‐on‐chip platform was designed to uncover subtype‐dependent responses to nanoparticle‐mediated photothermal therapy in breast cancer spheroids. The platform establishes a physiologically relevant and controllable 3D system for precision evaluation of nanophotothermal cancer therapies.
Camila A. Salvego   +6 more
wiley   +1 more source

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