Results 51 to 60 of about 103,435 (271)

Friedreich's ataxia (GAA)n•(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae. [PDF]

PLoS Genetics, 2011
Expansions of trinucleotide GAA•TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA•TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)•(TTC)(230) stimulate mitotic crossovers in yeast about 10,
Wei Tang, Margaret Dominska, Patricia W Greenwell, Zachary Harvanek, Kirill S Lobachev, Hyun-Min Kim, Vidhya Narayanan, Sergei M Mirkin, Thomas D Petes   +8 more
doaj   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Single-Image High Dynamic Range Reconstruction via Improved HDRUNet with Attention and Multi-Component Loss

Applied Sciences
High dynamic range (HDR) imaging aims to overcome the limited dynamic range of traditional imaging systems and achieve effective restoration of the brightness and color of the real world.
Liang Gao, Xiaoyun Tong, Laixian Zhang
doaj   +1 more source

Fibromyalgia as an independent risk factor for takotsubo cardiomyopathy: a national inpatient sample case-control study [PDF]

Exploration of Cardiology
Aim: Takotsubo cardiomyopathy (TTC) is an acute form of systolic dysfunction triggered by physical or emotional stress, most commonly seen in postmenopausal women.
Ishani Desai, Poojita Chinmay, Gyanendra K. Sharma, Neal L. Weintraub   +3 more
doaj   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Blood clot stabilization on root dentin conditioned by the combination of tetracycline and EDTA

Brazilian Journal of Oral Sciences, 2015
Aim: To assess the combined use of tetracycline (TTC) and ethylenediaminetetraacetic acid (EDTA) on clot formation, considering that EDTA may neutralize TTC acidity. Methods: Planed human tooth roots were treated with saline solution, EDTA, TTC and their
Gustavo Giacomelli Nascimento, Amauri Antiquera Leite, Elza Regina Manzolli Leite, José Eduardo Cezar Sampaio, Fábio Renato Manzolli Leite   +4 more
doaj   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Clinical Significance of High Expression of tRF-Glu-TTC-2 in Prostate Carcinoma and its Effect on Growth

American Journal of Men's Health, 2022
The tRNA-derived fragments (tRFs) are a new class of regulatory noncoding RNAs and have different biological functions in cancer. This article investigated the expression and clinicopathological significance of tRF-Glu-TTC-2 in prostate carcinoma (PCa ...
Lei Wang, Yaxin Liu, Wenqing Yan, Caihong Huang, Zhiyan Ding, Jiajia Yang, Shuwan Jiang, Lei Sun   +7 more
doaj   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Discussion on the Development of Integrated and Intelligent Space TTC＆OC Network

天地一体化信息网络, 2021
With the continuous development of aerospace applied research, the space system is rapidly developing towards space networking, integrated operation and intelligent service.Therefore, how to construct an integrated and intelligent space TTC＆OC network ...
Wei ZHANG, Tao WU, Hong MA, Yiwen JIAO, Yang CAI   +4 more
doaj   +2 more sources