Results 21 to 30 of about 981,982 (189)
Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences
Advanced Science, EarlyView.This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu +7 more
wiley +1 more source
a note on the tu-deng function
, 2012 2009年,Tu和Deng在一个组合猜想成立的基础上,构造了同时具有最优代数免疫性、最优代数次数和高非线性度的一类偶数元布尔函数.这类函数被称为Tu-Deng函数.基于同一猜想,Tu和Deng又构造了同时具有次最优代数免疫性、最优代数次数和较高非线性度的一类偶数元的l -阶弹性函数.通过研究由Tu-Deng函数导出的两个布尔函数的级联的密码学性质,在Tu-Deng猜想成立的基础上,给出一类奇数元的1 -阶弹性布尔函数.这类函数同时具有次最优代数免疫性、最优代数次数和较高非线性度.In 2009 ...
张方国, 杜育松
core +1 more source
Generalized Foulkes' Conjecture and Tableaux Construction [PDF]
, 2004 Foulkes conjectured that for n=ab and a ≤ b, every irreducible module occurring as a constituent in 1Sb∫SaSn occurs with greater or equal multiplicity in 1Sa∫SbSn.
Vessenes, Rebecca +1 more
core +1 more source
A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans
Advanced Science, EarlyView.This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao +19 more
wiley +1 more source
Advanced Science, EarlyView.Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen +13 more
wiley +1 more source
Fuglede`s conjecture fails in dimension 4 [PDF]
, 2005 In this note we modify a recent example of Tao and give an example of a set Omega subset of R-4 such that L-2(Omega) admits an orthonormal basis of exponentials {1/vertical bar Omega vertical bar 1/2 e(2 pi i )}(xi epsilon Lambda) for some set Lambda ...
Matolcsi, Máté
core +1 more source
Sustainable Materials Design With Multi‐Modal Artificial Intelligence
Advanced Science, EarlyView.Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu +8 more
wiley +1 more source
On a weakness of the Tu-Deng function and its repair [PDF]
, 2009 We observe that the function introduced by Z. Tu and Y. Deng in the ePrint Archive paper 2009/272 is weak against fast algebraic attacks. We propose an alternative function sharing all the properties of the Tu-Deng function but having not this ...
Claude Carlet
core +1 more source
ON THE THIRD SMARANDACHE CONJECTURE ABOUT PRIMES [PDF]
, 2001 In this paper one basically verifies the third Smarandache conjecture on ...
Le, Maohua
core +1 more source
Advanced Science, EarlyView.This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang +11 more
wiley +1 more source