Results 101 to 110 of about 3,019,050 (308)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Simulation and Test for Piezoelectric Composite Tube

open access: yesMATEC Web of Conferences, 2016
Piezoelectric composite circular tube has been developed,this tube is used for underwater acoustic transducer. The finite element simulation has been done for piezoelectric composite material tube, and gained the tube structure parameters.
Wang Hongwei
doaj   +1 more source

Self sealing disconnect for tubing forms metal seal after breakaway [PDF]

open access: yes, 1964
Disconnect fittings form a positive metal seal when the fill tube pulls against a metal sleeve when disconnected by force. A specially designed sleeve surrounds the fill tube.
Gernandt, H. H.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Resonance tube igniter [PDF]

open access: yes, 1970
Reasonance induced in stoichiometric mixtures of gaseous hydrogen-oxygen produces temperatures /over 1100 deg F/ high enough to cause ignition. Resonance tube phenomenon occurs when high pressure gas is forced through sonic or supersonic nozzle into ...
Conrad, E. W.   +2 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Internally stressed polymeric composite/metal cylinders: Manufacturing, testing and quality verifying by simplified procedure [PDF]

open access: yesScientific Technical Review, 2017
In this paper the details about manufacturing of multilayer cylinders consisting of metal liner (obtained by standard machining procedures) and polymeric composite material (produced by filament winding technology) are presented. For multilayer cylinders
Radulović Jovan, Žegarac Nikša
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Multi-spectroscopic investigation of the structure of single-wall carbon nanotubes

open access: yes, 2003
We present a multispectroscopic structural study of various nanotube samples with different tube diameters. We determine for each sample the mean bundle and tube diameter as well as the tube diameter distribution.
Anglaret, Eric   +2 more
core   +4 more sources

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