Results 71 to 80 of about 48,107 (266)

Collection of non-meconium stool on fecal occult blood cards is an effective method for fecal microbiota studies in infants

Microbiome, 2017
Background Effective methods are needed to collect fecal samples from children for large-scale microbiota studies. Stool collected on fecal occult blood test (FOBT) cards that can be mailed provides an effective solution; however, the quality of ...
Wendy S.W. Wong, Nicole Clemency, Elisabeth Klein, Marina Provenzano, Ramaswamy Iyer, John E. Niederhuber, Suchitra K. Hourigan   +6 more
doaj   +1 more source

Nonlinear waves in a viscous fluid contained in a viscoelastic tube

Zeitschrift für angewandte Mathematik und Physik, 2001
The author studies the wave propagation in a prestressed viscoelastic thin tube containing a viscous Newtonian fluid. A reductive perturbation technique is used to study the propagation of weakly nonlinear waves in the longwave approximation. Travelling wave solutions to various related equations are also obtained.
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CROP COEFFICIENT, DRY MATTER PARTITION AND SEEDLINGS QUALITY OF Hymenaea courbaril L. IN CONTAINERS SIZES UNDER WATER DEFICIT IRRIGATION1

Revista Árvore, 2017
Native species seedlings are commonly used in the degraded areas reforestation, riparian forests and legal reserve. Among the factors that influence the seedlings quality, are the container size and the substrate water availability.
César Antônio da Silva, Durval Dourado Neto, Cícero José da Silva   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Pericardiocentesis simulation model: conception and development [PDF]

Acta Cirúrgica Brasileira
Purpose: To develop a pericardiocentesis (PCT) simulation model applied for undergraduate medical training. Methods: A PCT simulator consisted of a torso mannequin, a silicone rubber heart (SRH), a container, and a filling system.
Yury Tavares de Lima, Larissa Holanda Gomes, Luiza Matias Marques, Igor Castelo Branco Fontenele Costa, Pedro Henrique Araújo Marques, Josue Viana Castro   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Development of an integrated fingerstick blood self-collection device for radiation countermeasures.

PLoS ONE, 2019
We report the development of system for packaging critical components of the traditional collection kit to make an integrated fingerstick blood collector for self-collecting blood samples of 100 μl or more for radiation countermeasures.
Jian Gu, Alan Norquist, Carla Brooks, Mikhail Repin, Sanjay Mukherjee, Jerome Lacombe, Jianing Yang, David J Brenner, Sally Amundson, Frederic Zenhausern   +9 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source