Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Heterotopic Pregnancy in a Unicornuate Uterus: A Case of Ruptured Rudimentary Horn. [PDF]
Sabeti N +4 more
europepmc +1 more source
A bio‐integrated nerve guidance conduit is developed for facial nerve regeneration by combining electrospun aligned PLCL nanofibers with a conductive tannic acid/polypyrrole‐based hydrogel coating. This optimized scaffold provides synergistic topographical cues and supports electrical stimulation, promoting enhanced neuronal differentiation and ...
Su Jeong Park +7 more
wiley +1 more source
Ventilation-assisted functional visualization: a stepwise workflow for planned management of a preoperatively identified tracheal diverticulum during thyroidectomy. [PDF]
Li F, Sun W, Sun L.
europepmc +1 more source
Silicon anodes in sulfide SSBs face coupled electrochemo‐mechanical failure by interface instability. This review examined recent advances and proposed mitigation strategies via material‐, electrode/interface‐, and cell‐level‐ engineering. We further evaluate scalable synthesis of sulfide SEs.
Murugesan Karuppaiah +4 more
wiley +1 more source
Delayed Vaginal Cuff Ectopic Pregnancy Following Hysterectomy: A Case Report. [PDF]
Nshimiyumuremyi E +11 more
europepmc +1 more source
Abstract Emulsion separation remains a persistent challenge in chemical and process industries due to the metastable nature of dispersed droplets. In gravity separators, the overall separation rate is governed by the formation of a densely packed zone (DPZ) of deforming and coalescing droplets that mediates between the dispersed and continuous phases ...
Andrei Zlobin +8 more
wiley +1 more source
Negative Contrast Esophagography Does Not Exclude Dehiscence After Boerhaave Repair: Complementary Low-Insufflation Carbon Dioxide Endoscopy. [PDF]
Jung HS, Rim GM, Shim YM, Kim KW.
europepmc +1 more source
Pancreaticoduodenal artery aneurysm presenting with retroperitoneal haemorrhage and gastric outlet obstruction: a case report. [PDF]
Naing SSS.
europepmc +1 more source
Blunt Trauma-Induced Chylothorax in Noonan Syndrome: A Rare Clinical Presentation. [PDF]
Wiblin R +3 more
europepmc +1 more source

