Results 251 to 260 of about 348,390 (367)

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

MedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei   +10 more
wiley   +1 more source

Developmental enamel defects in tuberous sclerosis: a clinical genetic marker? [PDF]

, 1997
Niamh Flanagan, William O’Connor, Bernard E. McCartan, Steven P. Miller, Joe McMenamin, Robin W. Watson   +5 more
openalex   +1 more source

Vitiligo

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 8, Page 968-987, August 2025.
Summary Vitiligo is a common pigment disorder of the skin resulting in destruction of melanocytes. Non‐segmental vitiligo (NSV) is an autoimmune disorder. The etiopathogenesis of segmental vitiligo (SV) remains incompletely understood. Genetic predisposition and increased vulnerability of melanocytes towards stressors lead to a melanocyte‐specific CD8+
Markus Böhm, Adrian Tanew
wiley   +1 more source

Tuberous sclerosis complex-associated kidney disease in children. [PDF]

Pediatr Nephrol
Marlais M, Mekahli D.
europepmc   +1 more source

Analysis of bothTSC1 andTSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis

, 1999
Yo Niida, Nicole Lawrence-Smith, Ashleigh Banwell, Erica Hammer, Janine Lewis, Roberta L. Beauchamp, Katherine B. Sims, Vijaya Ramesh, Laurie J. Ozelius   +8 more
openalex   +1 more source

Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3. [PDF]

, 1996
Timothy C. Burn, Timothy D. Connors, Terence J. Van Raay, William R. Dackowski, John M. Millholland, K. Klinger, Gregory M. Landes   +6 more
openalex   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Neurocutaneous features of tuberous sclerosis complex: A case report from Bangladesh. [PDF]

Medicine (Baltimore)
Iqbal MI, Osman F.
europepmc   +1 more source

The GAP-Related Domain of Tuberin, the Product of the TSC2 Gene, is a Target for Missense Mutations in Tuberous Sclerosis

, 1997
Magitha M. Maheshwar, Jeremy P. Cheadle, Adriane C. Jones, J Myring, Alan Fryer, Peter C. Harris, Julian R. Sampson   +6 more
openalex   +1 more source

Long‐Term Course of West Syndrome Associated with Tuberous Sclerosis [PDF]

, 1998
Katsuyuki Fukushima, Yushi Inoue, Tateki Fujiwara, Kazuichi Yagi   +3 more
openalex   +1 more source