Results 41 to 50 of about 29,889 (183)

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

open access: yesAdvanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng   +16 more
wiley   +1 more source

Problems of Gas Pressure Build-up in Casing String of UGS and Gas Wells [PDF]

open access: yesActa Montanistica Slovaca, 2006
This paper consists of three basic parts. The opening part is a brief description of problems associated with the secondary untightness of UGS wells (Underground Gas Storages) and gas wells generally.The main part of the paper is composed of some cases ...
Peter Sovius   +3 more
doaj  

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

open access: yesAdvanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu   +8 more
wiley   +1 more source

Research and Test on Water Drainage Gas Recovery Velocity String Technology for Horizontal Well

open access: yesShiyou jixie, 2018
The fracturing technology without pulling string adopted in horizontal well in Sulige tight gas field results in large number of tools used in the wellbore, in addition, high well inclination makes the foam drainage, plunger gas lift and production ...
Zhao Binbin   +5 more
doaj  

Novel methods by using non-vacuum insulated tubing to extend the lifetime of the tubing [PDF]

open access: yes, 2015
The analysis of the failure mechanics, namely hydrogen permeation of vacuum insulated tubing (VIT), indicated that the failure of VIT could be decreased but could not be avoided.
Zhou CL(周成龙)   +16 more
core   +1 more source

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

open access: yesAdvanced Science, EarlyView.
This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou   +3 more
wiley   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu   +15 more
wiley   +1 more source

Rigless Advancements: Enhancing Electric Submersible Pump Reliability Through Cable Deployment

open access: yesEnergies
Electric Submersible Pumps (ESPs) are widely deployed in high-flowrate wells but are constrained by frequent failures and the need for rig-based interventions.
Majid M. Rafie   +3 more
doaj   +1 more source

Tubing-Electrospinning: A One-Step Process for Fabricating Fibrous Matrices with Spatial, Chemical, and Mechanical Gradients

open access: yes, 2016
Guiding newly generated tissues in a gradient pattern, thereby precisely mimicking inherent tissue morphology and subsequently arranging the intimate networks between adjacent tissues, is essential to raise the technical levels of tissue engineering and ...
Gyuhyung Jin (1793203)   +3 more
core   +1 more source

Characterizing Biopolymer Electrolytes in Zinc–Air Batteries: Challenges, Best Practices, and a Robust Workflow Guiding Future Research Paths

open access: yesAdvanced Energy Materials, EarlyView.
Bio‐based gel polymer electrolytes promise sustainable, mechanically adaptable zinc–air batteries, yet their progress is constrained by inconsistent characterization. This review critically links formulation, structure, interfaces, and cell performance, identifies methodological gaps under alkaline operating conditions, and proposes application ...
Matteo Milanesi   +6 more
wiley   +1 more source

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