Results 1 to 10 of about 109,157 (295)

In vivo and in situ evaluation of innovative approaches in dentin hypersensitivity treatment [PDF]

BMC Oral Health
Background Dentin hypersensitivity (DH) causes transient sharp pain from exposed dentinal tubules, adversely affecting oral health and quality of life.
Heba Abd El-Fattah Mohamed, Dina Ezzeldin Mohamed, Elhassan Hassanein, Heba El-din Salah El-din Hamza   +3 more
doaj   +2 more sources

Early renal structural changes and potential biomarkers in diabetic nephropathy

Frontiers in Physiology, 2022
Diabetic nephropathy is one of the most serious microvascular complications of diabetes mellitus, with increasing prevalence and mortality. Currently, renal function is assessed clinically using albumin excretion rate and glomerular filtration rate.
Hao Liu, Jianguo Feng, Liling Tang
doaj   +1 more source

Disease Modeling with Kidney Organoids

Micromachines, 2022
Kidney diseases often lack optimal treatments, causing millions of deaths each year. Thus, developing appropriate model systems to study human kidney disease is of utmost importance.
Sophie Karp, Martin R Pollak, Balajikarthick Subramanian   +2 more
doaj   +1 more source

microRNA in Extracellular Vesicles Released by Damaged Podocytes Promote Apoptosis of Renal Tubular Epithelial Cells

Cells, 2020
Tubular injury and fibrosis are associated with progressive kidney dysfunction in advanced glomerular disease. Glomerulotubular crosstalk is thought to contribute to tubular injury.
Jin Seok Jeon, Eunbit Kim, Yun-Ui Bae, Won Mi Yang, Haekyung Lee, Hyoungnae Kim, Hyunjin Noh, Dong Cheol Han, Seongho Ryu, Soon Hyo Kwon   +9 more
doaj   +1 more source

Renalase's expression and distribution in renal tissue and cells. [PDF]

PLoS ONE, 2012
To study renalase's expression and distribution in renal tissues and cells, renalase coded DNA vaccine was constructed, and anti-renalase monoclonal antibodies were produced using DNA immunization and hybridoma technique, followed by further ...
Feng Wang, Tao Xing, Junhui Li, Mei Bai, Ruimin Hu, Zhonghua Zhao, Shoufu Tian, Zhigang Zhang, Niansong Wang   +8 more
doaj   +1 more source

Impact of Diabetic Stress Conditions on Renal Cell Metabolome

Cells, 2019
Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria ...
Simon Lagies, Roman Pichler, Tillmann Bork, Michael M. Kaminski, Kevin Troendle, Stefan Zimmermann, Tobias B. Huber, Gerd Walz, Soeren S. Lienkamp, Bernd Kammerer   +9 more
doaj   +1 more source

Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation

eLife, 2023
Excitation-contraction coupling requires a highly specialized membrane structure, the triad, composed of a plasma membrane invagination, the T-tubule, surrounded by two sarcoplasmic reticulum terminal cisternae.
Eline Lemerle, Jeanne Lainé, Marion Benoist, Gilles Moulay, Anne Bigot, Clémence Labasse, Angéline Madelaine, Alexis Canette, Perrine Aubin, Jean-Michel Vallat, Norma B Romero, Marc Bitoun, Vincent Mouly, Isabelle Marty, Bruno Cadot, Laura Picas, Stéphane Vassilopoulos   +16 more
doaj   +1 more source

Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury

Cell Communication and Signaling, 2023
Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
Elena Roger, Christos E. Chadjichristos, Panagiotis Kavvadas, Gareth W. Price, Chelsy L. Cliff, Safia Hadjadj, Jessy Renciot, Paul E. Squires, Claire E. Hills   +8 more
doaj   +1 more source

In Situ Single Photon Confocal Imaging of Cardiomyocyte T-tubule System from Langendorff-Perfused Hearts

Frontiers in Physiology, 2015
Transverse tubules (T-tubules) are orderly invaginations of the sarcolemma in mammalian cardiomyocytes. The integrity of T-tubule architecture is critical for cardiac excitation-contraction coupling function.
Biyi eChen, Caimei eZhang, Ang eGuo, Long-Sheng eSong   +3 more
doaj   +1 more source

Equine Hoof Wall Deformation: Novel Aspects Revealed

Small Structures, 2023
The equine hoof wall has a unique hierarchical structure that allows it to survive high‐impact scenarios. Previous authors have explored the compressive, viscoelastic, and fracture control properties of the hoof wall and suggested that this complex ...
Benjamin S. Lazarus, Rachel K. Luu, Samuel Ruiz-Pérez, Josiane D. V. Barbosa, Iwona Jasiuk, Marc A. Meyers   +5 more
doaj   +1 more source