Results 101 to 110 of about 286,999 (386)

Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix‐Dependent Manner for Spinal Cord Repair Applications

Advanced Healthcare Materials, EarlyView.
Through tuning biomimetic scaffold stiffness and matrix composition the reparative capacity of astrocyte progenitors is enhanced. Soft, collagen‐IV/fibronectin‐functionalized scaffolds promote progenitor growth while improving angiogenic, immunomodulatory, and neurotrophic capacity in a stiffness and matrix‐dependent manner, demonstrating the impact of
Cian O'Connor, Ian Woods, Sarah F. McComish, Sean Kerr, Matthew McGrath, Juan Carlos Palomeque Chávez, Jack Maughan, Tara McGuire, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +10 more
wiley   +1 more source

Interpretation of the concepts of dentinal tubule and dentinal canaliculus

Regulatory Mechanisms in Biosystems
The biology of dentin occupies a central place in the theory of tooth integrity as an organ, and knowledge about the microstructure of dentin changes with the development of new research methods, such as scanning electron microscopy.
S. L. Popel, N. O. Gevkaliuk, N. I. Sydliaruk, Y. M. Martyts, M. Y. Pynda, V. Y. Pudyak, V. Y. Krupey   +6 more
doaj   +1 more source

Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels

Scientific Reports, 2017
Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes the reduction of H2O2 and alkyl hydroperoxide and plays an important role in different biological processes.
Soomin Chae, Hyun-Kyung Lee, Yoo-Kyung Kim, Hyo Jung Sim, Yoorim Ji, Chowon Kim, Tayaba Ismail, Jeen-Woo Park, Oh-Shin Kwon, Beom-Sik Kang, Dong-Seok Lee, Jong-Sup Bae, Sang-Hyun Kim, Kyoung-Jin Min, Taeg Kyu Kwon, Mae-Ja Park, Jin-Kwan Han, Taejoon Kwon, Tae-Joo Park, Hyun-Shik Lee   +19 more
doaj   +1 more source

Tubule-U-Net: a novel dataset and deep learning-based tubule segmentation framework in whole slide images of breast cancer

Scientific Reports, 2023
The tubule index is a vital prognostic measure in breast cancer tumor grading and is visually evaluated by pathologists. In this paper, a computer-aided patch-based deep learning tubule segmentation framework, named Tubule-U-Net, is developed and ...
Eren Tekin, Çisem Yazıcı, Huseyin Kusetogullari, Fatma Tokat, Amir Yavariabdi, Leonardo Obinna Iheme, Sercan Çayır, Engin Bozaba, Gizem Solmaz, Berkan Darbaz, Gülşah Özsoy, Samet Ayaltı, Cavit Kerem Kayhan, Ümit İnce, Burak Uzel   +14 more
doaj   +1 more source

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

Kidney International, 2012
Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world and acute kidney injury (AKI) is now recognized as a major risk factor in its development.
I. Grgic, G. Campanholle, V. Bijol, Chang Wang, V. Sabbisetti, T. Ichimura, B. Humphreys, J. Bonventre   +7 more
semanticscholar   +1 more source

Advancements in Carbon‐Based Piezoelectric Materials: Mechanism, Classification, and Applications in Energy Science

Advanced Materials, EarlyView.
Carbon‐based piezoelectric materials are systematically categorized based on their structural and functional properties. The mechanisms of stress‐induced charge transfer are elucidated, and their applications are explored across three key domains: piezoelectric catalysis for energy conversion and environmental remediation, piezoelectric biomedical ...
Mude Zhu, Qingyou Liu, Wai‐Yeung Wong, Linli Xu   +3 more
wiley   +1 more source

A functional comparison of the cortical collecting tubule and the distal convoluted tubule. [PDF]

Journal of Clinical Investigation, 1975
Electrical and permeability features of the distal convoluted tubule (DCT) and the cortical collecting tubule (CCT) were examined using the technique in which isolated segments of rabbit tubules were perfused in vitro. When rabbits were given a regular diet and tubules were perfused and bathed in artificial solutions simulating plasma ultrafiltrate ...
J B Gross, J P Kokko, M Imai
openaire   +3 more sources

Enhanced MCP-1 Release in Early Autosomal Dominant Polycystic Kidney Disease

Kidney International Reports, 2021
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) causes kidney failure typically in adulthood, but the disease starts in utero. Copeptin, epidermal growth factor (EGF), and monocyte chemoattractant protein-1 (MCP-1) are associated with ...
Peter Janssens, Jean-Paul Decuypere, Stéphanie De Rechter, Luc Breysem, Dorien Van Giel, Jaak Billen, An Hindryckx, Luc De Catte, Marcella Baldewijns, Kathleen B.M. Claes, Karl M. Wissing, Koen Devriendt, Bert Bammens, Isabelle Meyts, Vicente E. Torres, Rudi Vennekens, Djalila Mekahli   +16 more
doaj  

3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake

Scientific Reports, 2022
Three-dimensional, organ-on-chip models that recapitulate kidney tissue are needed for drug screening and disease modeling. Here, we report a method for creating a perfusable 3D proximal tubule model composed of epithelial cells isolated from kidney ...
Jeffrey O. Aceves, Szilvia Heja, Kenichi Kobayashi, Sanlin S. Robinson, Tomoya Miyoshi, Takuya Matsumoto, Olivier J. M. Schäffers, Ryuji Morizane, Jennifer A. Lewis   +8 more
doaj   +1 more source

VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo. [PDF]

, 2015
Lysosomes are classically viewed as vesicular structures to which cargos are delivered for degradation. Here, we identify a network of dynamic, tubular lysosomes that extends throughout Drosophila muscle, in vivo. Live imaging reveals that autophagosomes
Davis, Graeme W, Hauswirth, Anna G, Johnson, Alyssa E, Shu, Huidy, Tong, Amy   +4 more
core   +3 more sources