Results 111 to 120 of about 286,999 (386)

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation

Nature Communications, 2020
It is unclear how the T-tubule structure of skeletal muscle, which regulates coordinated muscle contraction, forms. Here, the authors develop a four-dimensional quantitative model for T-tubule formation in zebrafish, based on live imaging, proposing a ...
Thomas E. Hall, Nick Martel, Nicholas Ariotti, Zherui Xiong, Harriet P. Lo, Charles Ferguson, James Rae, Ye-Wheen Lim, Robert G. Parton   +8 more
doaj   +1 more source

Theory of Cylindrical Tubules and Helical Ribbons of Chiral Lipid Membranes

, 1995
We present a general theory for the equilibrium structure of cylindrical tubules and helical ribbons of chiral lipid membranes. This theory is based on a continuum elastic free energy that permits variations in the direction of molecular tilt and in the ...
A. E. Jacobs, A. S. Rudolph, A. Singh, A. Tardieu, B. M. Peek, B. N. Thomas, C.-M. Chen, C.-M. Chen, D. R. Nelson, D. S. Chung, E. Sackmann, F. C. MacKintosh, F. C. MacKintosh, G. A. Hinshaw, G. A. Hinshaw, H. S. Seung, J. A. N. Zasadzinski, J. H. Georger, J. M. Schnur, J. M. Schnur, J. M. Schnur, J. S. Chappell, J. S. Chappell, J. V. Selinger, J. V. Selinger, M. A. Markowitz, M. Markowitz, N. Nakashima, P. Nelson, P. Yager, P. Yager, P. Yager, P.-G. de Gennes, R. Shashidhar, R. Treanor, S. A. Langer, S. L. Brandow, S. L. Burkett, T. C. Lubensky, T. C. Lubensky, T. Tachibana, W. Helfrich, W. Helfrich, X. Qiu   +43 more
core   +1 more source

Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue

Advanced Science, EarlyView.
Extracellular matrix remodeling is crucial in cancer progression. Using a peptide to probe the tension of ECM fibers, it was found that Fibronectin fibers gradually lose tension as human breast carcinoma progresses, while their tension is maintained in ductal carcinoma in situ (DCIS), the non‐invasive precursor of breast cancer. This loss of tension is
Arnaud Miéville, Charlotte M. Fonta, Cornelia Leo, Lucine Christe, Jörg Goldhahn, Gad Singer, Viola Vogel   +6 more
wiley   +1 more source

Mechanotransduction in the renal tubule

American Journal of Physiology-Renal Physiology, 2010
The role of mechanical forces in the regulation of glomerulotubular balance in the proximal tubule (PT) and Ca2+signaling in the distal nephron was first recognized a decade ago, when it was proposed that the microvilli in the PT and the primary cilium in the cortical collecting duct (CCD) acted as sensors of local tubular flow.
Sheldon Weinbaum, Yi Duan, Tong Wang, Lisa M. Satlin, Alan M. Weinstein   +4 more
openaire   +4 more sources

A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance [PDF]

, 2015
The exposure of insects to xenobiotics, such as insecticides, triggers a complex defence response necessary for survival. This response includes the induction of genes that encode key Cytochrome P450 monooxygenase detoxification enzymes.
Brinzer, Robert A., Cabrero, Pablo, Davies, Shireen-A., Dow, Julian A.T., Halberg, Kenneth A., Terhzaz, Selim   +5 more
core   +2 more sources

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling

Cell Reports, 2018
Summary: Distal nephron remodeling contributes to the pathophysiology of many clinically relevant scenarios, including diuretic resistance and certain Mendelian disorders of blood pressure.
Turgay Saritas, Victor G. Puelles, Xiao-Tong Su, James A. McCormick, Paul A. Welling, David H. Ellison   +5 more
doaj  

Segment-specific expression of 2P domain potassium channel genes in human nephron. [PDF]

, 2004
BackgroundThe 2P domain potassium (K2P) channels are a recently discovered ion channel superfamily. Structurally, K2P channels are distinguished by the presence of two pore forming loops within one channel subunit. Functionally, they are characterized by
Bockenhauer, Detlef, Goldstein, Steve AN, Levy, Daniel I, Velazquez, Heino   +3 more
core   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source