Results 131 to 140 of about 286,999 (386)

Label‐Free Dual‐Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury

open access: yesAdvanced Science, EarlyView.
This work develops a 3D label‐free photoacoustic/super‐resolution ultrasound imaging system as a comprehensive non‐invasive tool for acute kidney injury (AKI) study. This technique visualizes the intricate structure of renal microvessels and provides critical physiological insights, including renal hemodynamics and oxygenation.
Shensheng Zhao   +5 more
wiley   +1 more source

Ring around the tubule [PDF]

open access: yesThe Journal of Cell Biology, 2006
![Graphic][1] Coils of kinesin-13 (arrows) surround a microtubule. The kinesin protein family is in the trucking business, hauling vesicles and other cellular cargo along the microtubules. The family's black sheep is kinesin-13, which disassembles the filaments while riding on them.
openaire   +2 more sources

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

open access: yesAdvanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan   +12 more
wiley   +1 more source

A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusion

open access: yeseLife, 2018
Transdifferentiation is the poorly understood phenomenon whereby a terminally differentiated cell acquires a completely new identity. Here, we describe a rare example of a naturally occurring transdifferentiation event in zebrafish in which kidney distal
Richard W Naylor   +3 more
doaj   +1 more source

Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus [PDF]

open access: yes, 2017
A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy (DN), but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the ...
Bahamonde, Javiera   +3 more
core  

Numerical Observation of a Tubular Phase in Anisotropic Membranes [PDF]

open access: yes, 1997
We provide the first numerical evidence for the existence of a tubular phase, predicted by Radzihovsky and Toner (RT), for anisotropic tethered membranes without self-avoidance.
Gudmar Thorleifsson   +11 more
core   +4 more sources

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

open access: yesAdvanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen   +9 more
wiley   +1 more source

Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship [PDF]

open access: yes, 2018
Diabetic nephropathy (DN) is the most frequent cause of chronic renal failure. Until now, the pathophysiological mechanisms that determine its development and progression have not yet been elucidated.
Agüero, Rocio   +4 more
core  

Size, Shape and Low Energy Electronic Structure of Carbon Nanotubes

open access: yes, 1996
A theory of the long wavelength low energy electronic structure of graphite-derived nanotubules is presented. The propagating $\pi$ electrons are described by wrapping a massless two dimensional Dirac Hamiltonian onto a curved surface. The effects of the
C. L. Kane   +13 more
core   +1 more source

The proximal tubule in the pathophysiology of the diabetic kidney.

open access: yesAmerican Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2011
Diabetic nephropathy is a leading cause of end-stage renal disease. A better understanding of the molecular mechanism involved in the early changes of the diabetic kidney may permit the development of new strategies to prevent diabetic nephropathy.
V. Vallon
semanticscholar   +1 more source

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