Results 151 to 160 of about 286,999 (386)

Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development.

open access: yesCardiovascular Research, 2013
AIMS Emerging evidence indicates a critical role for junctophilin-2 (JP2) in T-tubule integrity and assembly of cardiac dyads in adult ventricular myocytes.
Biyi Chen   +12 more
semanticscholar   +1 more source

Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury

open access: yesAdvanced Science, EarlyView.
Dipyridamole acts as a clinically used compound to suppress ferroptosis. Dipyridamole down‐regulates the expression of RNF126, which is an E3 ligase to ubiquitinate SLC7A11 for proteasome degradation. The deficiency of SLC7A11 largely abolishes the protective role of dipyridamole both in vitro and in vivo.
Xiao Zhuang   +22 more
wiley   +1 more source

Placental RTN3L‐dependent ER‐Phagy Contributes to Fetal Testicular Dysplasia Upon Environmental Stress

open access: yesAdvanced Science, EarlyView.
Gestational environmental stress activates ER‐phagy by increasing placental Rtn3l mRNA N6‐methyladenosine modification, further inhibiting placental estradiol synthesis and contributing to fetal testicular dysplasia. This study demonstrates the early prevention and treatment of adult male infertility from the perspective of fetal‐derived diseases ...
Ye‐Xin Luo   +17 more
wiley   +1 more source

High‐Specificity Spatiotemporal Cholesterol Detection by Quadrature Phase‐Shifted Polarization Stimulated Raman Imaging

open access: yesAngewandte Chemie, EarlyView.
Utilizing quadrature phase modulation, the phase‐shifted polarization SRS (QP2‐SRS) microscope enables simultaneous measurement of the ρ‐related χ1111(3)$\chi _{1111}^{( 3 )}$ and χ1221(3)$\chi _{1221}^{( 3 )}$ components. In cholesterol molecular measurements, QP2‐SRS leverages the structural differences between cholesterol and other biomolecules to ...
Yongqing Zhang   +7 more
wiley   +2 more sources

Deletion of the insulin receptor in the proximal tubule promotes hyperglycemia.

open access: yesJournal of the American Society of Nephrology, 2013
Nearly all renal tubular epithelial cells express insulin receptor. The insulin receptor in the distal tubule appears to modulate BP, but the role of the insulin receptor in the proximal tubule is unknown.
Swasti Tiwari   +6 more
semanticscholar   +1 more source

Polyaspartic Acid‐Calcium‐Lanthanum Complexes Induce Antibacterial Remineralization of Dentin and In‐Depth Occlusion of Dentinal Tubules

open access: yesAdvanced Science, EarlyView.
Polyaspartic acid‐calcium‐lanthanum (PAsp‐Ca‐La) complexes could induce antibacterial remineralization of demineralized dentin and in‐depth occlusion of dentinal tubules (DTs) with lanthanum‐doped hydroxyapatite (La‐HAp) via polyelectrolyte‐cation complexes pre‐precursor (PCCP) process, allowing the release of La3+ in response to acids generated by ...
Ling Zhu   +12 more
wiley   +1 more source

Functional Characteristics of Nematocysts Found on the Scyphomedusa Cyanea Capillata [PDF]

open access: yes, 2007
Although prey capture by cnidarians is mediated through nematocysts, their influence on prey selection by cnidarians remains poorly documented. The difficulty in visualizing nematocyst–prey interactions remains the chief obstacle to understanding how the
Colin, Sean, Costello, John H.
core   +1 more source

A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart.

open access: yesHuman Molecular Genetics, 2013
The transverse (t)-tubule system plays an essential role in healthy and diseased heart muscle, particularly in Ca(2+)-induced Ca(2+) release (CICR), and its structural disruption is an early event in heart failure.
M. Ibrahim   +11 more
semanticscholar   +1 more source

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