Results 11 to 20 of about 122,654 (313)
Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation
eLife, 2023 Excitation-contraction coupling requires a highly specialized membrane structure, the triad, composed of a plasma membrane invagination, the T-tubule, surrounded by two sarcoplasmic reticulum terminal cisternae.
Eline Lemerle +16 more
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Frontiers in Physiology, 2015 Transverse tubules (T-tubules) are orderly invaginations of the sarcolemma in mammalian cardiomyocytes. The integrity of T-tubule architecture is critical for cardiac excitation-contraction coupling function.
Biyi eChen +3 more
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Pattern Formation of an Epithelial Tubule by Mechanical Instability during Epididymal Development
Cell Reports, 2014 A single epithelial tubule undergoes morphogenesis to form a functional shape during the development of internal organs; however, the mechanical processes that are directed by the molecular signals regulating tubular morphogenesis are poorly understood ...
Tsuyoshi Hirashima
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Equine Hoof Wall Deformation: Novel Aspects Revealed
Small Structures, 2023 The equine hoof wall has a unique hierarchical structure that allows it to survive high‐impact scenarios. Previous authors have explored the compressive, viscoelastic, and fracture control properties of the hoof wall and suggested that this complex ...
Benjamin S. Lazarus +5 more
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Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling
Cell Reports, 2018 Summary: Distal nephron remodeling contributes to the pathophysiology of many clinically relevant scenarios, including diuretic resistance and certain Mendelian disorders of blood pressure.
Turgay Saritas +5 more
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Journal of Family Medicine and Primary Care, 2020 Aim: Comparison of casein phosphopeptides (CPPs) and amorphous calcium phosphate (ACP), tricalcium phosphate, and hydroxyapatite on assessment of dentine tubule occlusion on primary enamel using scanning electron microscope (SEM).
Mebin George Mathew +5 more
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Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity. [PDF]
PLoS ONE, 2016 Exosomes are nanometer-scale, cell-derived vesicles that contain various molecules including nucleic acids, proteins, and lipids. These vesicles can release their cargo into adjacent or distant cells and mediate intercellular communication and cellular ...
Kishore Kumar Jella +5 more
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The role of renal proximal tubule transport in the regulation of blood pressure
Kidney Research and Clinical Practice, 2017 The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis.
Shoko Horita +6 more
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Communications Biology, 2023 Of late, numerous microphysiological systems have been employed to model the renal proximal tubule. Yet there is lack of research on refining the functions of the proximal tubule epithelial layer—selective filtration and reabsorption.
Ramin Banan Sadeghian +7 more
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Generation of proximal tubule spheroids for nephrotoxicity assessment [PDF]
Organoid, 2022 Background To date, nephrotoxicity in new drug development has been evaluated through two-dimensional culture of representative cell lines, such as HK-2 and human proximal tubule epithelial cells (hPTECs). Approximately 20% of new drugs that were safe in
Dae Hun Kim +3 more
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