Results 21 to 30 of about 286,999 (386)

Phases and Transitions in Phantom Nematic Elastomer Membranes [PDF]

open access: yes, 2004
Motivated by recently discovered unusual properties of bulk nematic elastomers, we study a phase diagram of liquid-crystalline polymerized phantom membranes, focusing on in-plane nematic order.
D. R. Nelson   +5 more
core   +1 more source

Impact of Diabetic Stress Conditions on Renal Cell Metabolome

open access: yesCells, 2019
Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria ...
Simon Lagies   +9 more
doaj   +1 more source

Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury

open access: yesCell Communication and Signaling, 2023
Background Without a viable cure, chronic kidney disease is a global health concern. Inflammatory damage in and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
Elena Roger   +8 more
doaj   +1 more source

The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster [PDF]

open access: yes, 2016
Malpighian tubules are critical organs for epithelial fluid transport and stress tolerance in insects, and are under neuroendocrine control by multiple neuropeptides secreted by identified neurons. Here, we demonstrate roles for CRF-like diuretic hormone
Cannell, Elizabeth   +5 more
core   +2 more sources

Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury.

open access: yesKidney International, 2002
BACKGROUND Traditional blood and urine markers for the diagnosis of various renal diseases are insensitive and nonspecific. Kidney Injury Molecule-1 (KIM-1) is a type 1 transmembrane protein, with an immunoglobulin and mucin domain, whose expression is ...
W. Han   +4 more
semanticscholar   +1 more source

Generation of proximal tubule spheroids for nephrotoxicity assessment [PDF]

open access: yesOrganoid, 2022
Background To date, nephrotoxicity in new drug development has been evaluated through two-dimensional culture of representative cell lines, such as HK-2 and human proximal tubule epithelial cells (hPTECs). Approximately 20% of new drugs that were safe in
Dae Hun Kim   +3 more
doaj   +1 more source

The proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction.

open access: yesAJP - Renal Physiology, 2016
There is an alarming global increase in the incidence of end-stage kidney disease, for which early biomarkers and effective treatment options are lacking.
R. Chevalier
semanticscholar   +1 more source

In Situ Single Photon Confocal Imaging of Cardiomyocyte T-tubule System from Langendorff-Perfused Hearts

open access: yesFrontiers in Physiology, 2015
Transverse tubules (T-tubules) are orderly invaginations of the sarcolemma in mammalian cardiomyocytes. The integrity of T-tubule architecture is critical for cardiac excitation-contraction coupling function.
Biyi eChen   +3 more
doaj   +1 more source

Identification of Multiple Functional Receptors for Tyramine on an Insect Secretory Epithelium [PDF]

open access: yes, 2017
The biogenic amine tyramine (TA) regulates many aspects of invertebrate physiology and development. Although three TA receptor subtypes have been identified (TAR1-3), specific receptors have not been linked to physiological responses in native tissue. In
Blumenthal, Edward M, Zhang, Haiying
core   +2 more sources

Equine Hoof Wall Deformation: Novel Aspects Revealed

open access: yesSmall Structures, 2023
The equine hoof wall has a unique hierarchical structure that allows it to survive high‐impact scenarios. Previous authors have explored the compressive, viscoelastic, and fracture control properties of the hoof wall and suggested that this complex ...
Benjamin S. Lazarus   +5 more
doaj   +1 more source

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