Results 51 to 60 of about 286,999 (386)
JACC: Basic to Translational Science, 2016 Cardiac myocytes from the mdx mouse, the mouse model of Duchenne muscular dystrophy, exhibit t-tubule disarray and increased calcium sparks, but a unifying molecular mechanism has not been elucidated.
Kurt W. Prins, MD, PhD +4 more
doaj +1 more source
Afadin orients cell division to position the tubule lumen in developing renal tubules [PDF]
, 2017 In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is not known. We recently found the F-actin binding protein Afadin is required for lumen continuity in developing renal ...
Brakeman, Paul R. +9 more
core +2 more sources
Frontiers in Physiology, 2017 Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a primary site of nephrotoxicity and resulting attrition in the drug development pipeline.
M. Gumz +16 more
semanticscholar +1 more source
Recrystallization of tubules from natural lotus (Nelumbo nucifera) wax on a Au(111) surface
Beilstein Journal of Nanotechnology, 2011 We present here the first results on the self-assembly of tubules of natural wax from lotus leaves on a single crystal Au(111) surface. A comparison of the tubule growth on Au(111) to that on HOPG is discussed.
Sujit Kumar Dora, Klaus Wandelt
doaj +1 more source
Micromachines, 2021 Kidney microphysiological systems (MPS) serve as potentially valuable preclinical instruments in probing mechanisms of renal clearance and osmoregulation. Current kidney MPS models target regions of the nephron, such as the glomerulus and proximal tubule
Stephanie Y. Zhang, Gretchen J. Mahler
doaj +1 more source
Kidney Proximal Tubule Lipoapoptosis Is Regulated by Fatty Acid Transporter-2 (FATP2).
Journal of the American Society of Nephrology, 2017 Albuminuria and tubular atrophy are among the highest risks for CKD progression to ESRD. A parsimonious mechanism involves leakage of albumin-bound nonesterified fatty acids (NEFAs) across the damaged glomerular filtration barrier and subsequent ...
Shenaz Khan +8 more
semanticscholar +1 more source
The Journal of Physiology, 2006 During the cardiac action potential, Ca2+ influx via L-type Ca2+ channels activates Ca2+ release channels (ryanodine receptors; RyRs) in adjacent sarcoplasmic reticulum (SR) membrane, causing Ca2+ release from the SR and thus contraction. There is increasing evidence that in ventricular myocytes the transverse (t-) tubules – invaginations of the ...
openaire +4 more sources
, 1997 We study the shape, elasticity and fluctuations of the recently predicted (cond-mat/9510172) and subsequently observed (in numerical simulations) (cond-mat/9705059) tubule phase of anisotropic membranes, as well as the phase transitions into and out of ...
Radzihovsky, Leo, Toner, John
core +1 more source
Adaptive changes in GFR, tubular morphology, and transport in subtotal nephrectomized kidneys: modeling and analysis [PDF]
, 2017 Removal of renal mass stimulates anatomical and functional adaptations in the surviving nephrons, including elevations in single-nephron glomerular filtration rate (SNGFR) and tubular hypertrophy. A goal of this study is to assess the extent to which the
Edwards, Aurelie +2 more
core +1 more source
Research Progress of Drug Delivery Systems Targeting the Kidneys
PharmaceuticalsChronic kidney disease (CKD) affects more than 10% of the global population, and its incidence is increasing, partially due to an increase in the prevalence of disease risk factors.
Li-Feng Huang +7 more
doaj +1 more source