Results 61 to 70 of about 109,157 (295)
Advanced Healthcare Materials, EarlyView.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
Scientific Reports, 2017 Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes the reduction of H2O2 and alkyl hydroperoxide and plays an important role in different biological processes.
Soomin Chae +19 more
doaj +1 more source
A functional comparison of the cortical collecting tubule and the distal convoluted tubule. [PDF]
Journal of Clinical Investigation, 1975 Electrical and permeability features of the distal convoluted tubule (DCT) and the cortical collecting tubule (CCT) were examined using the technique in which isolated segments of rabbit tubules were perfused in vitro. When rabbits were given a regular diet and tubules were perfused and bathed in artificial solutions simulating plasma ultrafiltrate ...
J B Gross, J P Kokko, M Imai
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz +2 more
wiley +1 more source
Enhanced MCP-1 Release in Early Autosomal Dominant Polycystic Kidney Disease
Kidney International Reports, 2021 Introduction: Autosomal dominant polycystic kidney disease (ADPKD) causes kidney failure typically in adulthood, but the disease starts in utero. Copeptin, epidermal growth factor (EGF), and monocyte chemoattractant protein-1 (MCP-1) are associated with ...
Peter Janssens +16 more
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Mechanotransduction in the renal tubule
American Journal of Physiology-Renal Physiology, 2010 The role of mechanical forces in the regulation of glomerulotubular balance in the proximal tubule (PT) and Ca2+signaling in the distal nephron was first recognized a decade ago, when it was proposed that the microvilli in the PT and the primary cilium in the cortical collecting duct (CCD) acted as sensors of local tubular flow.
Sheldon Weinbaum +4 more
openaire +4 more sources
Photocrosslinkable Kidney Decellularized Extracellular Matrix‐Based Bioink for 3D Bioprinting
Advanced Healthcare Materials, EarlyView.A photocrosslinkable bioink is developed from methacrylated decellularized porcine kidney extracellular matrix to create kidney‐specific 3D constructs. This bioink supports high cell viability, promotes multicellular spheroid formation, and enables stable multilayer bioprinting with tunable mechanical properties, providing a versatile platform for ...
Jaemyung Shin +5 more
wiley +1 more source
In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation
Nature Communications, 2020 It is unclear how the T-tubule structure of skeletal muscle, which regulates coordinated muscle contraction, forms. Here, the authors develop a four-dimensional quantitative model for T-tubule formation in zebrafish, based on live imaging, proposing a ...
Thomas E. Hall +8 more
doaj +1 more source
3D Bioprinted Renal Constructs Using Kidney‐Specific ECM Bioink System on Kidney Regeneration
Advanced Healthcare Materials, EarlyView.A kidney‐specific bioink derived from decellularized porcine kidney tissue supports the encapsulation, viability, and maturation of human primary kidney cells within 3D bioprinted constructs. In vivo, it also promotes the recruitment of host renal progenitor cells, collectively enhancing structural and functional regeneration of renal tissue.
Gabriel Carreno‐Galeano +4 more
wiley +1 more source
Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling
Cell Reports, 2018 Summary: Distal nephron remodeling contributes to the pathophysiology of many clinically relevant scenarios, including diuretic resistance and certain Mendelian disorders of blood pressure.
Turgay Saritas +5 more
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