Results 71 to 80 of about 286,999 (386)
Modeling oxygen consumption in the proximal tubule: effects of NHE and SGLT2 inhibition.
AJP - Renal Physiology, 2015 The objective of this study was to investigate how physiological, pharmacological, and pathological conditions that alter sodium reabsorption (TNa) in the proximal tubule affect oxygen consumption (QO2 ) and Na(+) transport efficiency (TNa/QO2 ).
A. Layton, V. Vallon, A. Edwards
semanticscholar +1 more source
Advanced Biology, EarlyView.Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang +6 more
wiley +1 more source
Design Engineering of a Bioartificial Renal Tubule Cell Therapy Device
Cell Transplantation, 1999 The use of a bioartificial renal tubule device composed of renal proximal tubule cells grown within a hollow fiber cartridge is a first step in engineering a bioartificial kidney to provide more complete replacement therapy of renal function than is ...
Janeta Nikolovski +2 more
doaj +1 more source
Three-dimensional structure of basal body triplet revealed by electron cryo-tomography. [PDF]
, 2011 Basal bodies and centrioles play central roles in microtubule (MT)-organizing centres within many eukaryotes. They share a barrel-shaped cylindrical structure composed of nine MT triplet blades.
Agard, David A +3 more
core +2 more sources
Who regenerates the kidney tubule?
Nephrology, Dialysis and Transplantation, 2015 The kidney possesses profound regenerative potential and in some cases can recover completely 'restitutio at integrum' following an acute kidney injury (AKI).
R. Kramann, T. Kusaba, B. Humphreys
semanticscholar +1 more source
Advanced Biology, EarlyView.Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers +3 more
wiley +1 more source
The Drosophila Malpighian tubule as a model for mammalian tubule function
Current Opinion in Nephrology and Hypertension, 2019 Studies of the genetic model organism, Drosophila melanogaster, have unraveled molecular pathways relevant to human physiology and disease. The Malpighian tubule, the Drosophila renal epithelium, is described here, including tools available to study transport; conserved transporters, channels, and the signaling pathways regulating them; and fly models ...
openaire +4 more sources
Weaving the Web of ER Tubules [PDF]
Cell, 2011 How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are shaped by the reticulons and DP1/Yop1p, whereas their fusion into a network is brought about by membrane-bound GTPases that include the atlastins, Sey1p, and ...
Junjie Hu +2 more
openaire +4 more sources
Journal of Indian Society of Periodontology, 2020 Context: Several studies have recommended the use of lasers in treatment of dentinal hypersensitivity. These materials have been used alone or in combination with an active desensitizing agent.
Praveen Jayaram +5 more
doaj +1 more source
A New Phase of Tethered Membranes: Tubules
, 1995 We show that fluctuating tethered membranes with {\it any} intrinsic anisotropy unavoidably exhibit a new phase between the previously predicted ``flat'' and ``crumpled'' phases, in high spatial dimensions $d$ where the crumpled phase exists. In this new
D. R. Nelson +9 more
core +1 more source