Results 81 to 90 of about 41,096 (247)
Engineering human JMJD2A tudor domains for an improved understanding of histone peptide recognition. [PDF]
Parkinson J +3 more
europepmc +1 more source
What drives animal responses to high severity fire? The role of functional traits
ABSTRACT Fire regimes are changing worldwide, with increases in the frequency, extent, and severity of fires posing growing risks to biodiversity. Fire severity – the degree of habitat alteration following fire – strongly influences both immediate survival and long‐term recovery of fauna.
Grace A. Vielleux +3 more
wiley +1 more source
ABSTRACT Walking football (WF) is an adapted low‐impact form of traditional football designed to promote physical activity and social interaction among older adults. However, evidence on its physiological demands—particularly energy expenditure expressed in metabolic equivalents (METs)—remains limited.
Silvia Varela +3 more
wiley +1 more source
The Scm FCS finger binds the Pcl Tudor domain to link canonical PRC1 and PRC2.1 in Drosophila
Abstract Canonical Polycomb Repressive Complex 1 (PRC1) was previously reported to selectively associate with Polycomb Repressive Complex 2.1 (PRC2.1) in cross‐linking‐based affinity purification experiments from Drosophila embryos, but the molecular basis of this interaction has remained unresolved.
Berfin Yesil +3 more
wiley +1 more source
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin +14 more
wiley +1 more source
Transcriptome analysis and identification of genes related to environmental adaptation of Grylloprimevala jilina Zhou & Ren 2023. [PDF]
Zhou Y +7 more
europepmc +1 more source
Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel.
openaire +1 more source
RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo +10 more
wiley +1 more source
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu +14 more
wiley +1 more source

