Results 91 to 100 of about 1,990 (201)
Multifaceted Biomarkers Suggest a Similar Profile of CNS Pathology in Relapsing and Progressive MS
European Journal of Neurology, Volume 32, Issue 2, February 2025.ABSTRACT Background Relapsing–remitting (RR) and primary progressive (PP) multiple sclerosis (MS) have distinct clinical courses, but underlying pathophysiological differences remain unclear. We compared pathological components between RRMS, PPMS, and other inflammatory and neurodegenerative disorders, leveraging soluble biomarkers and post‐mortem ...
Katelijn M. Blok +12 more
wiley +1 more source
Tumefactive demyelinating disease with isolated spinal cord involvement
Acta Radiologica Short Reports, 2014 Tumefactive multiple sclerosis (TMS) is an unusual variant of demyelinating disease. TMS has a variable and unknown progression and presents with features similar to a neoplasm making the determination a diagnostic challenge to clinicians.
Mina S Makary, Claudia F Kirsch
doaj +1 more source
Multicolored Stain-Free Histopathology with Coherent Raman Imaging [PDF]
, 2012 Conventional histopathology with hematoxylin & eosin (H&E) has been the gold standard for histopathological diagnosis of a wide range of diseases. However, it is not performed in vivo and requires thin tissue sections obtained after tissue biopsy, which ...
De Jager, Philip Lawrence +16 more
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The Neuroimaging Spectrum of Neurosarcoidosis
Clinical Neuroimaging, Volume 2, Issue 1, 2025.ABSTRACT Among its many forms, involvement of the nervous system in sarcoidosis ranks as one of the most severe and potentially disabling manifestations of the disease, and timely recognition and accurate diagnosis are critical for its optimal treatment.
Spencer K. Hutto, Gabriela A. Bou
wiley +1 more source
Identifying Tumefactive Demyelination on Synthetic MRI Myelin Maps
Case Reports in Radiology, Volume 2025, Issue 1, 2025.Tumefactive demyelinating lesions and brain neoplasms often present as a diagnostic challenge due to overlapping radiographic features among conventional imaging modalities ultimately resulting in uncertainty if a biopsy is warranted to establish a definitive diagnosis.
Brandon Simons +4 more
wiley +1 more source
Neurology Letters, 2023 In this lecture, multiple sclerosis variants will be discussed, which include Solitary Sclerosis, Schilder's disease, Baló's concentric sclerosis, Marburg variant of multiple sclerosis.
Ebrahim Kouchaki
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Chronic active lesions preferentially localize in watershed territories in multiple sclerosis
Annals of Clinical and Translational Neurology, Volume 11, Issue 11, Page 2912-2922, November 2024.Abstract Objective Paramagnetic rim lesions (PRLs) are a biomarker of chronic active lesions (CALs), and an important driver of neurological disability in multiple sclerosis (MS). The reason subtending some acute lesions evolvement into CALs is not known. Here we ask whether a relatively lower oxygen content is linked to CALs.
Ahmad A. Toubasi +14 more
wiley +1 more source
Journal of Neuroinflammation, 2019 Background Myelinoclastic diffuse sclerosis (MDS; also termed Schilder’s disease) is a rare inflammatory demyelinating disorder of the central nervous system characterised by demyelination of vast areas of the white matter. It is unclear whether MDS is a
S. Jarius +3 more
doaj +1 more source
Annals of Neurology, Volume 96, Issue 2, Page 276-288, August 2024.Objective To evaluate: (1) the distribution of gray matter (GM) atrophy in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder (AQP4+NMOSD), and relapsing–remitting multiple sclerosis (RRMS); and (2) the relationship between GM volumes and white matter lesions in ...
Rosa Cortese +60 more
wiley +1 more source
Virchow-Robin spaces : an anatomic variant or a pathologic sign? [PDF]
, 2009 Virchow-Robin spaces surround blood vessels. Their walls are formed by prolongations of the pia mater and they have no communication with the subarachnoid space. VRS are often seen as well-delineated foci of cerebrospinal fluid signal on MR images.
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