Results 161 to 170 of about 5,944,302 (351)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Type 1 Interferon Responses Underlie Tumor-Selective Replication of Oncolytic Measles Virus

, 2020
Sarah Aref, Anna Castleton, Katharine Bailey, Richard Burt, Aditi Dey, Daniel Leongamornlert, Rachel J. Mitchell, Dina Okasha, Adele K. Fielding   +8 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Value of couch height-based positioning in postoperative adjuvant radiotherapy for left-sided breast cancer

Scientific Reports
This study aimed to evaluate the value of positioning based on the treatment couch height in radiotherapy for left-sided breast cancer. Sixty patients who had undergone radical mastectomy for left-sided breast cancer were selected, with each patient ...
Zaichun Shang, Jian Chen, Ming Li, Binbin Ge, Jinjin Feng, Jianhua Jin, Jianting Wu, Hanzhen Ji, Kaiyue Chu, Xinhua Zhang   +9 more
doaj   +1 more source

Tumoral calcinosis [PDF]

Cleveland Clinic Journal of Medicine, 2021
Hiroyuki, Yano, Mitsuyo, Kinjo
openaire   +2 more sources

Unusual Ovarian Stromal Tumor with Radiation Changes Mimicking Carcinoma [PDF]

, 2011
Olga L. Bohn, Chengquan Zhao, Mirka W. Jones   +2 more
openalex   +1 more source

Lighting Up the Tumor—Fluorescein-Guided Resection of Gangliogliomas [PDF]

, 2020
Julius Höhne, Francesco Acerbi, Jacopo Falco, Mehmet Akçakaya, Nils Ole Schmidt, Talat Kırış, Camilla de Laurentis, Paolo Ferroli, Morgan Broggi, Karl-Michael Schebesch   +9 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Susceptibility toSalmonella typhimuriumInfection and Effectiveness of Vaccination in Mice Deficient in the Tumor Necrosis Factor Alpha p55 Receptor [PDF]

, 1998
Paul Everest, Mark Roberts, Gordon Dougan   +2 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source