Results 111 to 120 of about 10,254,505 (350)

Preparation and Preliminary Biological Evaluation of Novel ^99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents

Molecules, 2012
Two kinds of novel thymidine derivatives, <em>N</em>-thymidine-yl-<em>N′</em>-methyl-<em>N′</em>-{<em>N′′</em>-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-ethanediamine (TMHEA) and ...
Jiankang Zhang, Cheng Tan, Chunxiong Lu, Quanfu Jiang, Jie Tang   +4 more
doaj   +1 more source

Dosimetric validation of a magnetic resonance image gated radiotherapy system using a motion phantom and radiochromic film. [PDF]

, 2017
PurposeMagnetic resonance image (MRI) guided radiotherapy enables gating directly on the target position. We present an evaluation of an MRI-guided radiotherapy system's gating performance using an MRI-compatible respiratory motion phantom and ...
Berbeco, Brady, Chuang, Fayad, Freislederer, Garibaldi, Giraud, Jin, Keall, Kini, Koch, Lewis, Low, Malinowski, Nioutsikou, Ozhasoglu, Sanders, Seppenwoolde, Shiinoki, Shirato, Smith, Tacke, Voort, Wagman, Wiersma, Wojcieszynski, Wunderink, Yoganathan, Yousefi   +28 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Glutathione-Responsive Self-Assembled Magnetic Gold Nanowreath for Enhanced Tumor Imaging and Imaging-Guided Photothermal Therapy.

ACS Nano, 2018
Designing nanomaterials with advanced functions and physical properties to improve cancer diagnosis and treatment has been an enormous challenge. In this work, we report the synthesis of magnetic gold nanowreaths (AuNWs) by combining wet-chemical ...
Yijing Liu, Zhen Yang, Xiaolin Huang, Guocan Yu, Sheng Wang, Zijian Zhou, Zheyu Shen, Wenpei Fan, Yi Liu, M. Davisson, Heather Kalish, G. Niu, Z. Nie, Xiaoyuan Chen   +13 more
semanticscholar   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Multimode optical imaging for translational chemotherapy: in vivo tumor detection and delineation by targeted gallium corroles [PDF]

, 2011
We report the feasibility of tumor detection and delineation in vivo using multimode optical imaging of targeted gallium corrole (HerGa). HerGa is highly effective for targeted HER2+ tumor elimination in vivo, and it emits intense fluorescence.
Farkas, Daniel L., Gray, Harry B., Gross, Zeev, Hwang, Jae Youn, Medina-Kauwe, Lali K.   +4 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Imaging correlates of molecular signatures in oligodendrogliomas. [PDF]

, 2004
Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and
Betensky, Rebecca A, Cairncross, J Gregory, Forsyth, Peter A, Kachur, Edward, Lee, Donald H, Louis, David N, Megyesi, Joseph F, Mizoguchi, Masahiro, Okada, Yoshifumi, Sasaki, Hikaru, Zlatescu, Magdalena C   +10 more
core   +2 more sources

Gold Nanoparticles for Brain Tumor Imaging: A Systematic Review

Frontiers in Neurology, 2018
Background Demarcation of malignant brain tumor boundaries is critical to achieve complete resection and to improve patient survival. Contrast-enhanced brain magnetic resonance imaging (MRI) is the gold standard for diagnosis and pre-surgical planning ...
A. Meola, J. Rao, Navjot Chaudhary, Mayur Sharma, Steven D Chang   +4 more
semanticscholar   +1 more source