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Understanding the tumor immune microenvironment (TIME) for effective therapy
Nature Medicine, 2018 Vincent Chan +2 more
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Surgical Oncology, 2012
The concept of the tumor microenvironment, developed from Paget's "seed and soil" theory is made up of the cancer cells, the stromal tissue, and the extracellular matrix. In this mini-review, each of the components of this dynamic network will be examined.
Cynthia E. Weber, Paul C. Kuo
openaire +3 more sources
The concept of the tumor microenvironment, developed from Paget's "seed and soil" theory is made up of the cancer cells, the stromal tissue, and the extracellular matrix. In this mini-review, each of the components of this dynamic network will be examined.
Cynthia E. Weber, Paul C. Kuo
openaire +3 more sources
Eosinophils in the Tumor Microenvironment
2020Eosinophils are rare blood-circulating and tissue-infiltrating immune cells studied for decades in the context of allergic diseases and parasitic infections. Eosinophils can secrete a wide array of soluble mediators and effector molecules, with potential immunoregulatory activities in the tumor microenvironment (TME).
Mattei, Fabrizio +6 more
openaire +5 more sources
2010
Recent advances in stem cell and developmental neurobiology have uncovered new perspectives from which we investigate various forms of cancer. Specifically, the hypothesis at tumors are comprised of a subpopulation of malignant cells similar to stem cells is of great interest to scientists and clinicians and has been dubbed the cancer stem cell ...
Lissa C. Baird, Alexey V. Terskikh
openaire +3 more sources
Recent advances in stem cell and developmental neurobiology have uncovered new perspectives from which we investigate various forms of cancer. Specifically, the hypothesis at tumors are comprised of a subpopulation of malignant cells similar to stem cells is of great interest to scientists and clinicians and has been dubbed the cancer stem cell ...
Lissa C. Baird, Alexey V. Terskikh
openaire +3 more sources
Fibroblasts in the Tumor Microenvironment
2020The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors.
Truffi M., Sorrentino L., Corsi F.
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Leptin in Tumor Microenvironment
2020Leptin is a hormone that plays a major role as mediator of long-term regulation of energy balance, suppressing food intake, and stimulating weight loss. More recently, important physiological roles other than controlling appetite and energy expenditure have been suggested for leptin, including neuroendocrine, reparative, reproductive, and immune ...
Angelucci, A, Clementi, L, Alesse, E
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Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment
Cell, 2018 Elham Azizi +2 more
exaly +2 more sources
Parathyroid Tumor Microenvironment
2020Parathyroid tumors are the second most common endocrine neoplasia, and it is almost always associated with hypersecretion of the parathormone (PTH), involved in calcium homeostasis, causing primary hyperparathyroidism (PHPT). Parathyroid neoplasia has a stromal component particularly represented in atypical adenomatous and carcinomatous lesions ...
Verdelli, Chiara +2 more
openaire +3 more sources