Results 91 to 100 of about 5,001,621 (350)

A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

Science, 2018
SNF'ing out antitumor immunity Immune checkpoint inhibitors induce durable tumor regressions in some, but not all, cancer patients. Understanding the mechanisms that determine tumor sensitivity to these drugs could potentially expand the number of ...
D. Pan, Aya Kobayashi, Aya Kobayashi, Peng Jiang, L. F. Andrade, R. Tay, Adrienne M. Luoma, Daphne M Tsoucas, X. Qiu, Klothilda Lim, Prakash K. Rao, Henry W. Long, Guocheng Yuan, John G Doench, Myles A. Brown, X. Liu, K. Wucherpfennig   +16 more
semanticscholar   +1 more source

Renal pericytes: regulators of medullary blood flow [PDF]

, 2012
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Peppiatt-Wildman, Claire M., Kennedy-Lydon, T M, Wildman, S S P, Peppiatt-Wildman, C M, Peppiatt‐Wildman, C. M., Kennedy‐Lydon, T. M., Wildman, Scott S.P., Kennedy-Lydon, T. M., Crawford, C., Crawford, C, Wildman, S. S. P.   +10 more
core   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Huge schwannoma arising from the renal sinus: A case report with imaging and literature review

Radiology Case Reports
Renal sinus schwannomas are extremely rare. In this study, we inform a case of a large schwannoma that was suspected to have originated in the renal sinus based on preoperative imaging. A male in his 40s was referred to our hospital due to the incidental
Takahiro Yamamoto, MD, PhD, Akiko Narita, MD, PhD, Toshinobu Saga, MD, Hiroaki Okada, MD, PhD, Nozomu Matsunaga, MD, Hisashi Kawai, MD, PhD, Taiki Masumori, MD, PhD, Keishi Kajikawa, MD, PhD, Taishi Takahara, MD, PhD, Kojiro Suzuki, MD, PhD   +9 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Primary renal carcinoid tumor

Saudi Journal of Kidney Diseases and Transplantation, 2013
Primary renal carcinoid tumor is extremely rare and, therefore, its pathogenesis and prognosis is not well known. We report a primary renal carcinoid in a 26-year-old man treated by radical nephrectomy.
K V Kanodia, A V Vanikar, R D Patel, K S Suthar, V B Kute, P R Modi, H L Trivedi   +6 more
doaj   +1 more source

Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy

Clinical Cancer Research, 2014
Purpose: Immunomodulatory drugs differ in mechanism-of-action from directly cytotoxic cancer therapies. Identifying factors predicting clinical response could guide patient selection and therapeutic optimization.
J. Taube, A. Klein, J. Brahmer, Haiying Xu, Xiaoyu Pan, J. H. Kim, Lieping Chen, D. Pardoll, S. Topalian, R. Anders   +9 more
semanticscholar   +1 more source

Do Renal Tumor Characteristics Affect the Number of Hemostatic Agents Used During Partial Nephrectomy?

, 2019
Objective:The aim of this study was to investigate the use and types of hemostatic agents (HAs) used during partial nephrectomy (PN) and the relationship of the number of these agents used during surgery with tumor size, RENAL nephrometry score (NS ...
Hilal Şahin, Yusuf Özlem İlbey, Mehmet Yiğit Yalçın, Erdem Kısa, Cem Yücel, Mehmet Zeynel Keskin, Özgür Çakmak   +6 more
core   +1 more source

Renal Tumor Biopsy Technique

Chinese Medical Journal, 2016
Objective: To review hot issues and future direction of renal tumor biopsy (RTB) technique. Data Sources: The literature concerning or including RTB technique in English was collected from PubMed published from 1990 to 2015.
Lei Zhang, Xue-Song Li, Li-Qun Zhou
doaj   +1 more source

HMGB-1 - a novel mediator of inflammatory-induced renal epithelial mesenchymal transition

, 2010
Background: High mobility group box protein 1 (HMGB-1) is a chromatin binding protein that bends DNA thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has ...
Ryan, Michael P., Michael P. Ryan, Slattery, Craig, Tara McMorrow, Nolan, Stephen, Ronan Feighery, Craig Slattery, Feighery, Ronan, Stephen Nolan, Julie Lynch, Lynch, Julie, McMorrow, Tara   +11 more
core   +1 more source