Results 81 to 90 of about 2,379,573 (307)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma [PDF]

, 2012
Background: Epithelial-to-mesenchymal transition (EMT) has recently been implicated in the initiation and progression of renal cell carcinoma (RCC). Some mRNA gene expression studies have suggested a link between the EMT phenotype and poorer clinical ...
Antony C P Riddick, Stewart Grant D., Faratian Dana, Theodoulou Marianna, Grant D Stewart, Dana Faratian (171110), O'Mahony Fiach C., O'Mahony, Fiach C, James Varley (181899), David J. Harrison (171106), Jyoti Nanda (181902), Riddick, Antony C P, Varley James, Marianna Theodoulou, Dana Faratian, Varley, James, Riddick Antony C. P., Harrison David J., Fiach C O'Mahony, Antony C. P. Riddick (145315), Jyoti Nanda, Harrison, David J, David J Harrison, O'Mahony, Fiach C., Faratian, Dana, Riddick, Antony C. P., Nanda Jyoti, Marianna Theodoulou (181905), Grant D. Stewart (145312), Theodoulou, Marianna, Nanda, Jyoti, Stewart, Grant D., James Varley, Stewart, Grant D, Fiach C. O'Mahony (181892), Harrison, David J., Harrison, David J.; id_orcid   +36 more
core   +3 more sources

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

, 2013
The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification ...
Moch, H, Montironi, Rodolfo, Hes, O, Egevad, Lars, Epstein, Jonathan I., Hes O., Grignon, David, Hes, Ondrej, Tickoo, Satish K., Srigley, John R, Argani, Pedram, Egevad, L,, Argani P., Grignon, D, Tickoo S. K., Montironi, R, Zhou M., Moch, Holger, Eble, John N., Delahunt, B, Tickoo, Satish K, Grignon D., Delahunt B., Srigley J. R., Epstein, JI, Srigley, JR, Srigley, John R., The ISUP Renal Tumor Panel, Eble J. N., Epstein J. I., Zhou, Ming, Epstein, Jonathan I, Eble, JN, Egevad L., Moch H., Delahunt, Brett, Eble, John N, Tickoo, SK, Hes O, Delahunt B, Argani P, Moch H, Srigley JR, Tickoo SK, Eble JN, Epstein JI, Montironi R, Egevad L, Grignon D, Zhou M   +49 more
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Recognizing A Low-Grade Oncocytic Renal Tumor

, 2021
Oncocytic renal tumors are sometimes challenging since oncocytic morphology found in several renal tumors due to the lack of a standardized diagnosis. Some tumors with "borderline or intermediate" features are descriptively reported as "oncocytic" and/or
Keçeli, Avni Merter, Bayramoğlu, Zeynep, Gönen, Murat, Dönmez, Muhammet İrfan, Muhammet İrfan Dönmez, Avni Merter Keçeli, Zeynep Bayramoğlu, Murat Gönen   +7 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Clinical observation of a patient with a papillary tumor of the kidney with reversed nuclear polarity

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Papillary renal tumor with reverse nuclear polarity is a rare neoplasm with a favorable prognosis, recently identified separately in the classification of tumors of the urinary tract (2022).
T. A. Garkusha, D. D. Gerasimov, D. V. Davidova, F. V. Alyab'ev, N. V. Khludneva   +4 more
doaj   +1 more source