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Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Tumors of the airway can be classified into malignant (squamous and adenoidcystic) and low-grade or benign neoplasms. The most common tumors are squamous cancer and adenoidcystic, occurring in about equal numbers. Pre- and intraoperative evaluations are mandatory, along with strict attention to technical details and postoperative care.
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tumores de glándulas salivales mayores [PDF]
Se estudiaron 174 tumores de las glándulas salivales mayores recogidos de los archivos del Departamento de Patología del Instituto Nacional de Cancerologia en un período de 15 años (1954-1968).
Martin Berdasco, Franscisco +3 more
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
IntroductionPrecision in clinical practice is essential for optimizing patient outcomes and quality of life. To enhance diagnostic accuracy and treatment efficacy, various healthcare studies — including those on breast cancer — have increasingly adopted ...
Isabella Cristina Cazagranda +5 more
doaj +1 more source
Tumores odontogênicos benignos invasivos : aspectos imaginológicos
A maior parte dos tumores odontogênicos benignos comporta-se de modo não agressivo; porém, o ameloblastoma, o tumor odontogênico ceratocístico e o mixoma odontogênico são considerados tumores invasivos, pois apresentam comportamento biológico agressivo e
Larissa Donato Ribeiro, Maria Clara Ferraz Lima de Moura Maniçoba
core
Tumores de los conductos biliares [PDF]
Conferencia dictada en el Instituto Nal. de Cancerología. Los tumores benignos de los conductos biliares son relativamente raros. Christopher, que ha revisado recientemente este asunto, sólo pudo encontrar cuarenta y un casos publicados.
Santiago Triana Cortés +1 more
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source

