Results 71 to 80 of about 9,251 (267)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Immune-Related Peripheral Neuropathy Associated with Immune Checkpoint Inhibitors: Case Report and Review of Literature

Case Reports in Oncological Medicine
Immune checkpoint inhibitors (ICIs) are a group of drugs that have improved outcomes for patients with various cancers. Generally considered safe and well tolerated, these drugs are occasionally linked to immune-mediated or immune-related adverse events.
Carlos Eduardo Bonilla, Vaneza Ávila
doaj   +1 more source

Tumor [PDF]

Operative Neurosurgery, 2019
J Bradley, Elder, Jonathan H, Sherman, Daniel M, Prevedello, Nicholas J, Szerlip, Daniel E, Spratt, Ammar, Shaikhouni, Ahmed, Mohyeldin, Roberto J, Perez-Roman, Simon S, Buttrick, Sheikh C, Ali, Ricardo J, Komotar, Alexandre, Todeschini, Mostafa, Shahein, Juan Manuel, Revuelta, Douglas, Hardesty, Ricardo L, Carrau, Gabriel, Zada, Steven, Giannotta, David, Dornbos, Russell R, Lonser   +19 more
openaire   +2 more sources

Odontogenic Tumors

Journal of Craniofacial Surgery, 2013
This study aims to analyze the frequency and distribution of odontogenic tumors in a Greek population and compare the findings with those reported in the recent literature.Records of the Department of Oral Medicine and Pathology, Dental School, University of Athens, with histologic diagnosis of odontogenic tumors (based on the World Health Organization
Chrysomali, E., Leventis, M., Titsinides, S., Kyriakopoulos, V., Sklavounou, A.   +4 more
openaire   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

[Cardiac tumors].

Pathologica, 2005
Primary cardiac tumors are rare and their subdivision often difficult because of their unknown origin. In the most recent classification, cardiac tumors are divided into benign (about 75% and malignant neoplasms in relationship to their tissue differentiation (rhabdomyoma, haemangioma, etc.) or uncertain aetiology (myxoma, papillary fibroelastoma ...
ORLANDI, AUGUSTO, FERLOSIO, AMEDEO, Angeloni, C, Ciucci, A, SPAGNOLI, LUIGI GIUSTO   +4 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

PARENTAL EXPOSURE TO ENVIRONMENTAL MICROPOLLUTANTS AND ITS ASSOCIATION WITH CLINICOPATHOLOGICAL FEATURES AND EARLY TREATMENT OUTCOMES IN ACUTE LEUKEMIA

Hematology, Transfusion and Cell Therapy
Leukemia is the most common hematological malignancy in the pediatric population, accounting for approximately 30% of all cancer diagnoses among children under 15 years of age.
Micael DANGUI MENEZES, Kennia SILVA, Ana Luiza GOULART STARCK, Gustavo SCHROLL DOS PRAZERES, Laura Gabriela CARDOSO, Fausto CELSO TRIGO, Geise ELLEN BROTO, Marla KARINE AMARANTE, Carolina PANIS   +8 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source