Results 131 to 140 of about 66,124 (248)

Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis

, 2022
Guillermo Solís‐Fernández, Ana Montero‐Calle, Maricruz Sánchez-Martínez, Alberto Peláez‐García, María Jesús Fernández‐Aceñero, Pilar Pallarés, Miren Alonso‐Navarro, Marta Mendiola, Jelle Hendrix, David Hardisson, Rubén A. Bartolomé, Johan Hofkens, Susana Rocha, Rodrigo Barderas   +13 more
openalex   +2 more sources

Mutant p53 elicits context-dependent pro-tumorigenic phenotypes [PDF]

, 2021
Jennifer J. McCann, Irina A. Vasilevskaya, Christopher McNair, Peter Gallagher, Neermala Poudel Neupane, Renée de Leeuw, Ayesha A. Shafi, Emanuela Dylgjeri, Amy C. Mandigo, Matthew J. Schiewer, Karen E. Knudsen   +10 more
openalex   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Pluripotent stem cell-derived extracellular vesicles: Cell type-dependent effect on tumorigenicity in cancer cell lines. [PDF]

J Cell Commun Signal
Du C, Narayanan K, Ganapathy A, Wan ACA.
europepmc   +1 more source

Long-term implantation test and tumorigenicity of polyvinyl alcohol hydrogel plates [PDF]

, 2001
Tatsuo Nakamura, Hiroki R. Ueda, Tohru Tsuda, Yong-Ho Li, Tetsuya Kiyotani, Masatoshi Inoue, Kunio Matsumoto, Takashi Sekine, Yu Liu, Suong‐Hyu Hyon, Yasuhiko Shimizu   +10 more
openalex   +1 more source

The Activation of Protamine 1 Using Epigenome Editing Decreases the Proliferation of Tumorigenic Cells

, 2022
Hadjer Namous, Camila Urbano Braz, Yiding Wang, Hasan Khatib   +3 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Human induced pluripotent stem cell-derived neural stem/progenitor cell therapy for spinal cord injury: preclinical advances and translational perspectives. [PDF]

Stem Cells Transl Med
Ogaki R, Nagoshi N, Okano H, Nakamura M.
europepmc   +1 more source

High‐Content SRS Imaging Unveils Altered Cholesterol Metabolism in Ovarian Cancers Under CAR‐T Treatment

Advanced Science, EarlyView.
High‐content Stimulated Raman Scattering (SRS) Imaging reveals that ovarian cancer cells surviving Chimeric Antigen Receptor (CAR) ‐T cell challenge exhibit increased cholesterol esterification. Pharmacological inhibition of this pathway with Avasimibe significantly enhances CAR‐T induced killing of ovarian cancer cells by reducing cancer cell ...
Chinmayee V. Prabhu Dessai, Zhuoying Huang, Haonan Lin, Guangrui Ding, Hongjian He, Menna Siddiqui, Meng Zhang, Wilson Wong, Ji‐Xin Cheng   +8 more
wiley   +1 more source