Results 171 to 180 of about 66,124 (248)

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

BMP9 Modulates IL-33 Signaling to Mitigate EndMT in Pulmonary Arterial Hypertension. [PDF]

Hypertension
Becher C, Groeneveld EJ, Quarck R, Neep B, Pan X, Szulcek R, Tu L, Guignabert C, Bogaard HJ, Yu PB, de Man F, Sanchez-Duffhues G, Goumans MJ.   +12 more
europepmc   +1 more source

Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity [PDF]

, 2006
Joshua P. Cantor, Dimitrios Iliopoulos, Atul Rao, Teresa Druck, Shuho Semba, Shuang‐Yin Han, Kelly A. McCorkell, Thiru V. Lakshman, Joshua E. Collins, Phyllis Wachsberger, Joseph S. Friedberg, Kay Huebner   +11 more
openalex   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

IL-33-induced neuroimmune regulation in depression: A narrative review from molecular mechanisms to therapeutic potential. [PDF]

Medicine (Baltimore)
Wang G, Zhang X, Duan G, Yuan S.
europepmc   +1 more source

Lentivirus‑mediated RNA interference inhibits the tumorigenicity of cluster of differentiation 44+ tumor cells in hypopharyngeal cancer

, 2017
Chenling Shen, Bin Ye, Haixia Hu, Chen Nie, Yan Ma, Jingrong Lv, Hao Wu, Mingliang Xiang   +7 more
openalex   +2 more sources

PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes [PDF]

, 2017
Deepak Kumar Singh, Omid Gholamalamdari, Mahdieh Jadaliha, Xiao Ling Li, Yo-Chuen Lin, Yang Zhang, Shuomeng Guang, Seyedsasan Hashemikhabir, Saumya Tiwari, Yuelin J. Zhu, Abid Khan, Anu Thomas, Arindam Chakraborty, Virgilia Macias, André Balla, Rohit Bhargava, Sarath Chandra Janga, Jian Ma, Supriya G. Prasanth, Ashish Lal, Kannanganattu V. Prasanth   +20 more
openalex   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Endothelial dysfunction and cardiac damage indicators in patients with β-thalassemia major under iron-chelation therapy. [PDF]

Ther Adv Hematol
Al-Sanabra OM, Abbas MA, Hazà WJ, Hazàa AA.   +3 more
europepmc   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source