Results 201 to 210 of about 66,124 (248)

KMT2C Loss Promotes NF2‐Wildtype Meningioma Progression and Ferroptosis Sensitivity via Epigenetic Repression of Hippo Signaling

Advanced Science, EarlyView.
In NF2–wild‐type meningiomas, loss of the epigenetic regulator KMT2C suppresses NF2 transcription and inactivates Hippo signaling, driving tumor progression and increasing ferroptosis sensitivity. Restoration of histone acetylation reverses these effects and inhibits tumor growth, identifying KMT2C as a key regulator linking epigenetic control, NF2 ...
Liuchao Zhang, Yangfan Ye, Wei Gu, Xinyue Wang, Nuo Chen, Qixin He, Lei Xu, Pengzhan Zhao, Guoqiang Fu, Guangyao Yuan, Wenqian Shi, Honglu Chao, Yiming Tu, Jing Ji   +13 more
wiley   +1 more source

Optimization of Culture Media for Human Umbilical Cord-Derived Mesenchymal Stem Cell Production. [PDF]

Stem Cells Int
Chu W, Liu M, Shangguan Y, He F, Zeng X, Guo T, Li T, Zhang F, Wang Q, Wu J, Zhong Z, Liang X.   +11 more
europepmc   +1 more source

In vitro and in vivo characterization of murine bone marrow stromal stem cells: self renewal, differentiation, tumorigenic potential

, 2009
Maria Teresa Esposito
openalex   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Safety Assessment of Stem Cell-Based Therapies: Current Standards and Advancing Frameworks. [PDF]

Cells
Leonov GE, Grinchevskaya LR, Makhnach OV, Samburova MV, Goldshtein DV, Salikhova DI.   +5 more
europepmc   +1 more source

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense.

, 1990
John C. Reed, Michael Cuddy, Subrata Haldar, Carlo M. Croce, Peter C. Nowell̀, D Makover, Katherine Bradley   +6 more
openalex   +2 more sources

Engineered TIGIT‐Blockade Membrane Vesicles Synergize with Microwave Ablation to Mediate Liver Metastases Eradication

Advanced Science, EarlyView.
Microwave ablation (MWA) represents a highly effective and clinically significant therapeutic modality for the treatment of liver metastases. This study develops engineered cell membrane vesicles to specifically target the transition zone of MWA for liver metastases. This strategy can inhibit VEGF‐mediated immunosuppression, block CD155/TIGIT signaling
Shaoyue Li, Weichen Xu, Yuting Shen, Xuexia Shan, Jiawei Sun, Shisi Ding, Xiaodong Hou, Shaoning Zhang, Zhiyuan Niu, Taixia Wang, Xin Guan, Xiao Li, Weiwei Ren, Dou Du, Huixiong Xu, Wenwen Yue, Liping Sun   +16 more
wiley   +1 more source

Preclinical biodistribution and safety evaluation of human iPSC-derived dopaminergic neural progenitor cells for Parkinson's disease. [PDF]

Front Cell Dev Biol
Huang Y, Wen H, Li L, Li L, Li Q, Qin C, Mao Y, Lin Z, Jiang H, Zhu F, Li X, Geng X.   +11 more
europepmc   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Safety assessment of rat embryonic fraction for in vivo regenerative therapy

Biology Open
Sivarama Prasad Darsi, Somorita Baishya, Veerababu Nagati, Kala Kumar Bharani, Satyanarayana Swamy Cheekatla, Sujesh Kumar Darsi, Adi Reddy Kamireddy, Ram Reddy Barra, Ashok Kumar Devarasetti, Sreedhar Surampudi, Jayaram Reddy Singireddy, Siva Kumar Kandula, Anil Kumar Pasupulati   +12 more
doaj   +1 more source