Results 231 to 240 of about 155,806 (387)

Tumorigenic Potential of Extracellular Matrix Metalloproteinase Inducer [PDF]

, 2001
Stanley Zucker, Michelle Hymowitz, Ellen E. Rollo, Richard H. Mann, Cathleen Conner, Jian Cao, Hussein D. Foda, David C. Tompkins, Bryan P. Toole   +8 more
openalex   +1 more source

SLPI⁺ AT2‐Like Cells Orchestrate Lung Adenocarcinoma Invasion via Wnt Pathway Activation and Stromal Crosstalk in a Spatially Defined Margin Niche

Advanced Science, EarlyView.
Integrating spatial transcriptomics and single‐cell RNA sequencing, this study identifies a novel subpopulation of SLPI⁺ AT2‐like cells at the invasive margin of lung adenocarcinoma (LUAD). These cells, through stromal crosstalk and Wnt pathway activation, promote tumor stemness and invasion.
Zhoufeng Wang, Guonian Zhu, Pan Tang, Yan Wang, Wenxin Luo, Wenpeng Song, Zhikang Pan, Bingjie Zheng, YongChao Jiang, Defu Xiao, Xin Jin, Yong Bai, Guowei Che, Weimin Li   +13 more
wiley   +1 more source

Addressing the challenges of immunogenicity, heterogeneity and tumorigenicity in the clinical translation of human embryonic stem cells. [PDF]

Stem Cell Res Ther
Xia L, Qin J, Ye S.
europepmc   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Cancer stem cells in hepatocellular carcinoma: therapy resistance and emerging treatments. [PDF]

Front Immunol
Yadav DK, Yadav RK, Singh A, Huang Y, Bao D, Yang Z, Huang H, Jiang Y, Wang P, Lin S, Hua Y, Hu Y.   +11 more
europepmc   +1 more source

Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer

, 2011
Yuval Tabach, Ira Kogan-Sakin, Yosef Buganim, Hilla Solomon, Naomi Goldfinger, Randi Hovland, Xisong Ke, Anne M. Øyan, Karl-H. Kalland, Varda Rotter, Eytan Domany   +10 more
openalex   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

TIE1 Promotes Primary Tumor Growth by Inhibiting Apoptosis and Activating the AKT-p70S6K Signaling Pathway in Breast Cancer. [PDF]

Genes Cells
Azuma K, Matsuyama T, Watanabe S, Semba K, Nakayama J.   +4 more
europepmc   +1 more source

Inactivation of VHL by Tumorigenic Mutations That Disrupt Dynamic Coupling of the pVHL·Hypoxia-inducible Transcription Factor-1α Complex [PDF]

, 2004
Felicia M. Miller, Alex Kentsis, Roman Osman, Zhen‐Qiang Pan   +3 more
openalex   +1 more source

Bacteria acting with tumorigenic chaperones [PDF]

Protoplasma, 2019
openaire   +2 more sources