Results 241 to 250 of about 155,806 (387)

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Erratum: [Corrigendum] Characteristics of primary side population cervical cancer cells. [PDF]

Oncol Lett
Wei ZT, Yu XW, He JX, Liu Y, Zhang SL.
europepmc   +1 more source

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang   +14 more
wiley   +1 more source

BMP9 Modulates IL-33 Signaling to Mitigate EndMT in Pulmonary Arterial Hypertension. [PDF]

Hypertension
Becher C, Groeneveld EJ, Quarck R, Neep B, Pan X, Szulcek R, Tu L, Guignabert C, Bogaard HJ, Yu PB, de Man F, Sanchez-Duffhues G, Goumans MJ.   +12 more
europepmc   +1 more source

A PRELIMINARY NOTE ON THE CHROMOSOMES AND TUMORIGENICITY IN HUMAN-MOUSE SOMATIC CELL HYBRIDS

, 1972
Michihiro C. Yoshida
openalex   +2 more sources

Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF‐κB and TGF‐β Signaling Pathways

Advanced Science, EarlyView.
This research provides the first comprehensive evidence that PS‐MPs exacerbate ccRCC progression by activating the NF‐κB and TGF‐β pathways. These findings establish PS‐MPs as an environmental risk factor for ccRCC progression and identify the NF‐κB and TGF‐β signaling as potential therapeutic targets to mitigate the adverse effects of ‐PS‐MPs exposure.
Shiqi Ye, Jianfeng Xiang, Siqi Zhou, Qintao Ge, Aihetaimujiang Anwaier, Kun Chang, Gang Wei, Jiahe Lu, Xi Tian, Shuxuan Zhu, Yuchen Jiang, Wei Zhang, Tingting Cai, Moran Xu, Dingwei Ye, Danfeng Xu, Tao Wang, Hailiang Zhang, Wenhao Xu   +18 more
wiley   +1 more source

Author Correction: CREB5 promotes tumorigenicity and upregulates druggable cell surface modalities in basal-like breast cancer. [PDF]

NPJ Precis Oncol
Makovec A, Boytim E, Gustafson A, Ludwig M, Wang L, Ali A, Ishani K, Luo C, Bergom HE, John E, Tape S, Kellen S, Deacon A, Dewji FI, Richter C, Cookle L, Moline D, Rennhack JP, Drake JM, Antonarakis ES, Largaespada DA, Ostrander JH, Hwang J.   +22 more
europepmc   +1 more source

Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells [PDF]

, 2019
Ke Tang, Yuandong Yu, Liyan Zhu, Pingwei Xu, Jie Chen, Jingwei Ma, Huafeng Zhang, Haiqing Fang, Weiwei Sun, Li Zhou, Keke Wei, Fei Li, Jiadi Lv, Jing Xie, Yuying Liu, Bo Huang   +15 more
openalex   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

Autophagy inhibition in LGALS9-overexpressing nasopharyngeal carcinoma unleashes immune response. [PDF]

Autophagy
Pascual C, Klionsky DJ, Klionsky DJ.
europepmc   +1 more source