Results 201 to 210 of about 1,569,619 (249)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Preoperative selective arterial embolization followed by transurethral resection of bladder tumor for large bladder tumors: Early clinical experiences. [PDF]

Investig Clin Urol
Bang S, Joo SM, Kim DK, Kwon JK, Bang S, Shin D, Jeon J, Hong SH, Cho KS.   +8 more
europepmc   +1 more source

Deep learning ensemble models for CT-based differentiation of malignant and benign sacral bone tumors: development and evaluation. [PDF]

Insights Imaging
Yin P, Zheng F, Liu K, Liang K, Yang L, Lu L, Lang N, Li Y, Hong N.   +8 more
europepmc   +1 more source

Case Report: A Rare Presentation of Giant Multicompartmental Lipoma of Hand in a 3-Year-Old Child. [PDF]

Hand (N Y)
Gadgil S, Mula RB, Yenuganti S, Palo S.
europepmc   +1 more source

Corrigendum to "Clinically relevant somatic variants and genomic discordance between primary tumors and mediastinal lymph nodes in lung adenocarcinoma". [PDF]

Ther Adv Med Oncol
europepmc   +1 more source

Tumor markers in testis tumors.

The Turkish journal of pediatrics, 1984
openaire   +2 more sources