Results 201 to 210 of about 6,547,471 (339)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Assessment of Tumoricidal Efficacy and Response to Treatment with¹⁸F-FDG PET/CT After Intraarterial Infusion with the Antiglycolytic Agent 3-Bromopyruvate in the VX2 Model of Liver Tumor [PDF]

, 2011
Eleni Liapi, Jean-François H. Geschwind, Mustafa Vali, Afsheen Khwaja, Veronica Prieto-Ventura, Manon Buijs, Josephina A. Vossen, Shanmugasudaram Ganapathy, Richard L. Wahl   +8 more
openalex   +1 more source

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.

New England Journal of Medicine, 2002
G. Demetri, M. von Mehren, C. Blanke, A. D. Van den Abbeele, B. Eisenberg, P. Roberts, M. Heinrich, D. Tuveson, S. Singer, M. Janicek, J. Fletcher, S. Silverman, S. Silberman, R. Capdeville, B. Kiese, B. Peng, S. Dimitrijević, B. Druker, C. Corless, C. Fletcher, H. Joensuu   +20 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Preoperative endoscopic third ventriculostomy in children with posterior fossa tumors: an institution experience [PDF]

, 2012
Waleed A. Azab, Tarek M Alsheikh, Ahmed Yahia   +2 more
openalex   +1 more source

Tumor behavior disparities in all-cause and cause-specific mortality among patients with central nervous system tumors. [PDF]

Sci Rep
Gan Y, Zeng Y, Song X, Yuan Y, Li Y, Niu X.   +5 more
europepmc   +1 more source

Recent advances in bone and soft tissue tumors: lipomatous tumors [PDF]

, 2012
Creytens, David
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Cerebral tumor necrosis factor α expression and long-term neurocognitive performance after cardiopulmonary bypass in rats [PDF]

, 2009
Bettina Jungwirth, Kristine Kellermann, Ma Qing, G. Burkhard Mackensen, Manfred Blobner, E. Kochs   +5 more
openalex   +1 more source

Precise combination therapy of radiotherapy and immunotherapy guided by joint PD-L1 imaging and T-cell imaging. [PDF]

J Immunother Cancer
Yi H, Luo Q, Bai Z, Li X, Yu Y, Shi J, Ma X, Wang F.   +7 more
europepmc   +1 more source