Results 301 to 310 of about 6,547,471 (339)

Somatic genetic alterations in the development and progression in thyroid tumors of follicular cells. [PDF]

Eur Thyroid J
Calafato G, Di Paola FJ, De Leo A, Maloberti T, Coluccelli S, Poppi L, Repaci A, Solaroli E, Damiani S, Chillotti S, Chiarucci F, Rhoden KJ, de Biase D, Tallini G.   +13 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Molecular predictors of treatment resistance and recurrence following neoadjuvant therapy in rectal cancer. [PDF]

BMC Cancer
Huang F, McLeod MC, Irwin RK, Smithson M, Gao M, Hardiman KM, Chong Z.   +6 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Human Papilloma Virus Does Not Fully Inactivate p53 Cellular Activity in HNSCC. [PDF]

Head Neck
Gencel-Augusto J, Li H, Woerner LC, Tian N, Borah AA, Myers JN, Ha P, Johnson DE, Grandis JR.   +8 more
europepmc   +1 more source

Correction to ‘Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors’

Molecular Oncology, EarlyView.
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Case Report: Bilateral testicular teratoma in an infant with torsion of an intra-abdominal testis and contralateral testicular teratoma. [PDF]

Front Pediatr
Hua C, Fan H, Guo Z, Li X, Yang Y, Bi J.
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

The effect of neighborhood deprivation on access to surgical care for pediatric renal tumors. [PDF]

Pediatr Surg Int
Hsu PJ, Khosrovaneh K, Kunnath N, Ehrlich PF, Petroze RT, Gadepalli SK.   +5 more
europepmc   +1 more source