Results 171 to 180 of about 752,560 (269)

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Introduction of whole genome sequencing as NHS standard of care for glioma patients in two neurosurgical oncology centres: West Midlands. [PDF]

BJC Rep
Wykes V, Albanese E, Crispi V, Manan S, Khan T, Cole N, Bennett C, Hughes L, Vafadar N, Cheng V, Pohl U, Raghavan M, Wallis Y, Watts C.   +13 more
europepmc   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Does human cytomegalovirus provide a novel therapeutic target for patients with glioblastoma? [PDF]

Philos Trans R Soc Lond B Biol Sci
Söderberg-Naucler C, Pantalone MR, Stragliotto G, Bartek J.   +3 more
europepmc   +1 more source

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Regulatory T cells in liver metastases: emerging and divergent roles in tumour progression. [PDF]

eGastroenterology
Wu G, Yang T, Gholami S, DePeralta D, Weiss M, Deng M, Wang P, Huang H.   +7 more
europepmc   +1 more source

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression [PDF]

, 1985
Lucie Fransen, Rita Müller, Anne Marmenout, Jan Tavernier, José Van der Heyden, Eric Kawashima, André Chollet, Richard Tizard, H. Van Heuverswyn, Adri Van Vliet, Marie-Rose Ruysschaert, Walter Fiers   +11 more
openalex   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

Targeting CXCR2 in prostate cancer cells can block CD47-SIRPα interaction and reverse M2 macrophage polarization in the TME. [PDF]

Mol Cancer
Sun Y, Ren S, Wen W, Jing J, Luo X, Shao S, Duan R, Zeng G, Guo J.   +8 more
europepmc   +1 more source

Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo [PDF]

, 1998
Lynne Webster, R.J. Hodgkiss, George D. Wilson   +2 more
openalex   +1 more source