Results 181 to 190 of about 752,560 (269)

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

Sensory neuropeptide CGRP and its co-receptor RAMP1 drive tumour cell growth in gastrointestinal cancers. [PDF]

BMJ Oncol
Parathan P, Tran K, Neil L, Tan T, Carli ALE, Liao Y, Mouradov D, Da Gama Duarte J, Huber A, Pal B, Gibbs P, Sieber OM, Chiu IM, Kearney CJ, Shi W, Mariadason JM, Williams DS, Buchert M, Mielke LA.   +18 more
europepmc   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Inter-observer agreement in interpreting intraoperative ultrasonography during brain tumour surgery. [PDF]

Front Surg
Jamjoom AAB, Sluijters OJJ, Wildman J, Giampiccolo D, Charalambides C, Barua NU.   +5 more
europepmc   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

FEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li, XianShuai Xu, GuangZheng Liu, XiaoQian Lv, JiuZhou Song, HongYan Sun, YingJie Niu, QiSheng Zuo, Wei Han, BiChun Li, Kai Jin   +10 more
wiley   +1 more source

Dissemination of Mitochondrial DNA Variants: Looking at the 'Bigger' Picture of the Tumour Microenvironment in Rectal Cancer Patients. [PDF]

J Extracell Biol
Bakke KM, Bjørnetrø T, Bousquet PA, Sanabria AM, Meltzer S, Lüders T, Trøseid AS, Stang E, Negård A, Frøyen EA, Lunder AK, Lyckander LG, Aass HCD, Redalen KR, Ree AH.   +14 more
europepmc   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Inhibiting SLAMF8 modulates tumor-associated macrophages and restores CD8+ T cell-mediated antitumor immunity in colorectal cancer. [PDF]

Oncoimmunology
Han X, Bai X, Wang N, Sun Y, Hu J, Li L, Liu Z, Zhang Y, Liang Z, Sang L, Han L, Zhang Q, Qian X.   +12 more
europepmc   +1 more source

CASE OF ANEURYSMAL TUMOUR OF THE ORBIT, CURED BY TYING THE COMMON CAROTID ARTERY

George Busk
openalex   +2 more sources

Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma

, 2019
Victor Maximov, Zhihong Chen, Yun Wei, M. Hope Robinson, Cameron J. Herting, Nithya Shanmugam, Vasilisa A. Rudneva, Kelly C. Goldsmith, Tobey J. MacDonald, Paul A. Northcott, Dolores Hambardzumyan, Anna Marie Kenney   +11 more
openalex   +1 more source