Results 31 to 40 of about 8,142 (149)

The role of glycosaminoglycans and proteoglycans in atherosclerosis

Current Issues in Pharmacy and Medical Sciences, 2012
Numerous studies point out to the role of glycosaminoglycans (GAG) and proteoglycans (PG) in the pathogenesis of atherosclerosis. Both GAG and PG take part in the formation of tunica intima and tunica media, contribute to the neointima formation, and ...
Iwona Kaznowska-Bystryk
doaj   +1 more source

Pathogenesis of atherosclerosis in peripheral artery disease for diabetes patients [PDF]

Romanian Journal of Medical Practice, 2020
Over 170 million people worldwide are diagnosed with diabetes and it’s estimated that the number will reach 370 million cases by 2030. Diabetes represents a major risk factor for all cardiovascular diseases with a high mortality rate.
Pavelina Mihaela ANDREI, Maria Daniela TANASESCU, Alexandru MINCA, Andra-Elena BALCANGIU-STROESCU, Daniela BALAN, Andrada MIHAI, Alexandra Maria LIMBAU, Constantin IONESCU TIRGOVISTE   +7 more
doaj   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Comparative Microscopic Analysis of the Suboccipital and Intracranial Segments of the Vertebral Artery: Structural Variations and Clinical Implications in Indian Cadavers [PDF]

International Journal of Anatomy Radiology and Surgery
Introduction: The vertebral arteries are essential for cerebral circulation, supplying critical brain regions including the occipital and temporal lobes, brainstem, and cerebellum.
Jitendra Devialal Rawal, Nishita Kashyap Jethva, Maulik Dilipkumar Patel, Dhaval Vishnubhai Patel   +3 more
doaj   +1 more source

Repeated instillations of bleomycin in male mice induce a perivascular remodeling at distance of fibrotic areas in the context of progressive pulmonary fibrosis

Animal Models and Experimental Medicine, EarlyView.
We established a model of progressive pulmonary fibrosis via repeated intratracheal instillation (ITI) of leomycin (BLM) (A). Perivascular remodeling was observed in areas distant from the fibrotic areas and lesions induced by repeated ITI of BLM simulate those observed in IPF patients (B). Thus, this model has the capacity to track and investigate the
Céline‐Hivda Yegen, Zakaria Maakoul, Dominique Marchant, Patrice Callard, Julia Bourse, Jean‐François Bernaudin, Hilario Nunes, Carole Planès, Emilie Boncoeur, Nicolas Voituron   +9 more
wiley   +1 more source

Study of Morphometry and Elastic Fibre Distribution in Left and Right Coronary Arteries [PDF]

Journal of Krishna Institute of Medical Sciences University, 2019
Background: Coronary artery disease also called as ischemic heart disease which develops when major blood vessels that supply blood to heart become damaged or diseased. It is also one of the leading causes of death.
Ashwini R. Desai, S. K. Chavan
doaj  

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Estrutura, ultraestrutura e morfometria da aorta de paca (Cuniculus paca, Linnaeus, 1766) criada em cativeiro

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2012
Descreveram-se a morfologia, morfometria e ultraestrutura de segmentos das porções torácica e abdominal da aorta de quatro pacas (Cuniculus paca) adultas. Os segmentos aórticos foram analisados à microscopia de luz e à microscopia eletrônica de varredura.
S.P. Garcia Filho, L.L. Martins, A.C.G. Reis, M.R. Pacheco, M.R.F. Machado   +4 more
doaj   +1 more source