Results 41 to 50 of about 36,581 (262)

Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response inhibitors

npj Systems Biology and Applications
Combination therapy is well established as a key intervention strategy for cancer treatment, with the potential to overcome monotherapy resistance and deliver a more durable efficacy.
Orsolya Papp, Viktória Jordán, Szabolcs Hetey, Róbert Balázs, Valér Kaszás, Árpád Bartha, Nóra N. Ordasi, Sebestyén Kamp, Bálint Farkas, Jerome Mettetal, Jonathan R. Dry, Duncan Young, Ben Sidders, Krishna C. Bulusu, Daniel V. Veres   +14 more
doaj   +1 more source

Improvement in Weldment of Dissimilar 9% CR Heat-Resistant Steels by Post-Weld Heat Treatment

Metals, 2020
The effect of the post-weld heat treatment on the microstructures and mechanical properties of the dissimilar joint of G115, a novel developed martensite heat resistant steel, and CB2 steel, currently used in an ultra-super-critical power unit, was ...
Jiankun Xiong, Ting Li, Xinjian Yuan, Guijun Mao, Jianping Yang, Lin Yang, Jian Xu   +6 more
doaj   +1 more source

Evaluation of novel-objective functions in the design optimization of a transonic rotor by using deep learning

Engineering Applications of Computational Fluid Mechanics, 2021
Design optimization of transonic airfoils for rotary blades is a challenging subject that remarkably affects the stage and overall performance of axial-flow compressors.
A. Zeinalzadeh, M.R. Pakatchian
doaj   +1 more source

Low‐Angle Grain Boundaries and Re‐Segregation in Single‐Crystalline Ni‐Base Superalloys

Advanced Engineering Materials, EarlyView.
This work demonstrates that Re‐segregation at low‐angle grain boundaries (LAGBs) in Ni‐base superalloys is influenced by misorientation angle. Advanced microscopy and atom probe tomography reveal that higher misorientation angles increases Re‐segregation.
Alireza B. Parsa, Aparna Saksena, Alesander Kostka, Pascal Thome, Felicitas Scholz, Alexandre Mussi, Christoph Somsen, Baptiste Gault, Jan Frenzel, Gunther Eggeler   +9 more
wiley   +1 more source

Effect of rejuvenation heat treatment on re-service aging stability of γ′phase in directionally solidified superalloy

Journal of Aeronautical Materials, 2021
High temperature aging treatment was first conducted on the rejuvenated directionally solidified superalloy to simulate the re-service aging damage of turbine blades and the virgin directionally solidified superalloy respectively.
TANG Wenshu, XIAO Junfeng, NAN Qing, GAO Sifeng, LI Yongjun, ZHANG Jiong   +5 more
doaj   +1 more source

Productivity‐Driven Optimization of Laser Powder Bed Fusion Parameters for IN718 Superalloy: Process Control, Microstructure, and Mechanical Properties

Advanced Engineering Materials, EarlyView.
This study demonstrates how optimizing laser power, scanning speed, and hatching distance in laser powder bed fusion can boost the productivity of Inconel 718 manufacturing by up to 29% while maintaining mechanical integrity. The work delivers a validated process window and cost–time analysis, offering industry‐ready guidelines for efficient additive ...
Amir Behjat, Guido Barale, John Stavridis, Ehsan Norouzi, Jin‐Yoo Suh, Dong‐Ik Kim, Luca Iuliano, Abdollah Saboori   +7 more
wiley   +1 more source

A New Thermal Elasto-Hydrodynamic Lubrication Solver Implementation in OpenFOAM

Lubricants, 2023
Designing effective thermal management systems within transmission systems requires simulations to consider the contributions from phenomena such as hydrodynamic lubrication regions.
James Layton, Benjamin C. Rothwell, Stephen Ambrose, Carol Eastwick, Humberto Medina, Neville Rebelo   +5 more
doaj   +1 more source

Pyramidal Structures on Yttria‐Stabilized Zirconia after High Temperature Exposure at 1500°C: New Features on an Old Material

Advanced Engineering Materials, EarlyView.
New features on yttria‐stabilized zirconia after exposure at 1500°C: Newly discovered pyramidal structures on an old material. After exposure at 1550°C on the cross section of YSZ new features, namely pyramidal structures are discovered. These structures grow with time, increase in numbers, appear as singularities, are often arranged in strings, and ...
Doris Sebold, Dylan Jennings, Robert Vaßen   +2 more
wiley   +1 more source

Numerical study of a two-stage transonic fan dynamic characteristics in transient processes

Propulsion and Energy
The transient performance of aero-engine during acceleration and deceleration processes has a significant effect on the maneuverability of the aircraft.
Fan Liu, Zhipeng Cao, Chaobin Guan, Longbo Zhao, Xiao Niu, Hong Yan   +5 more
doaj   +1 more source

Monitoring thermoacoustic instability: A comparative analysis of feature-based and end-to-end deep learning approaches

Applications in Energy and Combustion Science
This paper compares two data-driven frameworks for monitoring thermoacoustic instability (TAI) in a gas turbine combustor. A conventional machine learning approach using handcrafted features is contrasted with an end-to-end deep learning method employing
Jikang Wang, Yichen Wang, Yupeng Qin, Xuan Lv   +3 more
doaj   +1 more source