Results 261 to 270 of about 2,722,658 (361)

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben   +4 more
wiley   +1 more source

Outpaced by Industry: Industrial Environments Reduce Endurance, With Implications for Evolutionary Fitness

open access: yesAmerican Journal of Biological Anthropology, Volume 190, Issue 1, May 2026.
ABSTRACT Objectives Physical function—the capacity to perform tasks requiring endurance and/or strength—is a key determinant of fitness that has directly influenced Homo sapiens' survival, reproduction and health throughout our evolutionary journey.
Daniel P. Longman   +16 more
wiley   +1 more source

Age‐related behavioral and molecular landmarks in new mouse models for studying Alzheimer's disease in Down syndrome

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Down syndrome (DS) is the leading genetic cause of intellectual disability and Alzheimer's disease (AD), with over 90% of individuals developing AD‐related dementia (DSAD). The triplication of the APP gene on chromosome 21 drives early amyloid‐β (Aβ) accumulation, but other Hsa21 genes also contribute to pathology.
Monika Rataj Baniowska   +18 more
wiley   +1 more source

VGLL3 Regulates DAPK2‐Mediated Autophagy During Osteoblast Differentiation

open access: yesBioFactors, Volume 52, Issue 3, May/June 2026.
VGLL3 regulates autophagic activity during osteoblast differentiation and is associated with DAPK2‐mediated autophagy. Overexpression of Dapk2 partially restores autophagy and osteogenic differentiation in Vgll3‐deficient osteoblasts. ABSTRACT Vestigial‐like family member 3 (VGLL3), a transcriptional cofactor of the TEA domain family, has been ...
Yuhan He   +7 more
wiley   +1 more source

When Carcinoma Meets Sarcoma: A Rare Case of Pancreatic Carcinosarcoma and Review of Literature

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Pancreatic carcinosarcoma is an extremely rare and aggressive malignancy with both epithelial and mesenchymal components. This case contributes to the limited global literature, emphasizing the importance of awareness, accurate diagnosis, and further research to improve understanding and management of this lethal tumor.
Pouria Abedini   +4 more
wiley   +1 more source

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