Results 51 to 60 of about 123,487 (310)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Low-Complexity Multiple-Component Turbo Decoding Aided Hybrid ARQ

, 2011
Previous research has focused on improving the throughput of Hybrid Automatic Repeat reQuest (HARQ) schemes. However, since turbo codes have been introduced into HARQ schemes, their complexity has increased owing to the iterative Bahl, Cocke, Jelinek and
Chen, Hong, Hanzo, Lajos, Maunder, Robert G.   +2 more
core   +1 more source

Perbandingan Nilai Bit Error Rate Penyandi Turbo dengan Sandi Komponen Konvolusional, Block dan Gabungan

Techne, 2019
Pada sistem komunikasi digital, dibutuhkan sistem penyandian kanal yang berfungsi untuk meminimalkan efek kerusakan atau hilangnya informasi yang diakibatkan oleh derau di dalam kanal. Sistem penyandian kanal yang baik memiliki nilai Bit Error Rate (BER)
Eva Yovita Dwi Utami, Ruth Johana Angelina, Andreas Ardian Febrianto   +2 more
doaj   +1 more source

The Influence of Ring-Speed Ratio Dynamic Change on Nonlinear Vibration Response of High-Speed Turbocharger Rotor System

Shock and Vibration, 2021
The ring-speed ratio is a comprehensive dynamic index of floating ring bearing structure and operating parameters, which directly affects the dynamic behavior of the turbocharger rotor system.
Guangfu Bin, Liang Zhang, Feng Yang, Anhua Chen   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Non-recursive max* operator with reduced implementation complexity for turbo decoding [PDF]

, 2012
In this study, the authors deal with the problem of how to effectively approximate the max?? operator when having n > 2 input values, with the aim of reducing implementation complexity of conventional Log-MAP turbo decoders.
P. T. Mathiopoulos, S. Papaharalabos, Papaharalabos, S., Mathiopoulos, P.T., Masera, Guido, Martina, Maurizio   +5 more
core   +1 more source

Optimization of 2‑Stage Turbocharged Gas SI Engine Under Steady State Operation

Journal of Middle European Construction and Design of Cars, 2017
The proposed paper deals with an optimization of a highly-turbocharged large-bore gas SI engine. Only steady state operation (constant engine speed and load) is considered.
Vítek Oldřich, Macek Jan, Klíma Jiří, Vacek Martin   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source