Results 81 to 90 of about 296,058 (324)

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

A Proposed Chaotic-Switched Turbo Coding Design and Its Application for Half-Duplex Relay Channel

Discrete Dynamics in Nature and Society, 2015
Both reliability and security are two important subjects in modern digital communications, each with a variety of subdisciplines. In this paper we introduce a new proposed secure turbo coding system which combines chaotic dynamics and turbo coding ...
Tamer H. M. Soliman, Fengfan Yang, S. Ejaz   +2 more
doaj   +1 more source

The LHCb Turbo stream [PDF]

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2016
Abstract The LHCb experiment will record an unprecedented dataset of beauty and charm hadron decays during Run II of the LHC, set to take place between 2015 and 2018. A key computing challenge is to store and process this data, which limits the maximum output rate of the LHCb trigger.
Puig A, LHCb trigger group
openaire   +2 more sources

Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion

Advanced Healthcare Materials, EarlyView.
Platelet quality deteriorates during storage due to protein and platelet adhesion to current bag materials. Here, polymer coatings are identified that reduce adhesion and translated them to mini‐storage bags. Platelet quality are not impacted, despite significantly reducing adhesion.
Nicolas Pereyra, Kai Yu, Jason Rogalski, Taylor Olivia Da Silva, Parisa Golesorkhi, Madeleine Goldstein, Dana V. Devine, Jayachandran N. Kizhakkedathu   +7 more
wiley   +1 more source

Turbo-Aggregate: Breaking the Quadratic Aggregation Barrier in Secure Federated Learning [PDF]

, 2020
Federated learning is a distributed framework for training machine learning models over the data residing at mobile devices, while protecting the privacy of individual users.
Avestimehr, A. Salman, Guler, Basak, So, Jinhyun   +2 more
core   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source

A Review on Reactor Design and Surface Modification of Atomic Layer Deposition for Functional Nanoparticles

Advanced Materials Interfaces, EarlyView.
In this review, the fundamentals, main challenges, and reactor configurations spanning temporal atomic layer deposition (ALD) to spatial ALD have been systematically reviewed. Furthermore, applications of surface modification using particle ALD in the fields of energy, catalysis, luminescence, and human health are introduced. This review aims to assist
Guanghui Yan, Gaoshan Huang, Jianjun Shi, Yi Ouyang, Xueqin Zuo, Zhihao Bao, Yongfeng Mei   +6 more
wiley   +1 more source

Thermal Annealing Enhances Piezoelectricity and Regenerative Potential of PVDF‐TrFE Nanofiber Scaffolds

Advanced Materials Technologies, EarlyView.
Thermal annealing improves the structure, stiffness, and piezoelectric properties of poly(vinylidene flouride‐trifluoroethylene) (PVDF‐TrFE) nanofiber scaffolds. These annealed scaffolds promote Schwann cell proliferation and matrix remodeling in vitro and demonstrate in vivo biocompatibility.
Maksym Krutko, Holly M. Poling, Maulee Sheth, Supasek Kongsomros, Andrew E. Bryan, Manju Sharma, Akaljot Singh, Hasan A. Reza, Kathryn A. Wikenheiser‐Brokamp, Takanori Takebe, Michael A. Helmrath, Greg M. Harris, Leyla Esfandiari   +12 more
wiley   +1 more source

Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut‐Liver‐on‐a‐Chip Models

Advanced Science, EarlyView.
The effects of intestinal epithelial cells and their exosomes on the hepatic differentiation of HPCs are explored in a gut‐liver‐on‐a‐chip. Exosomes from intestinal epithelial cells improve liver fibrosis. Moreover, the miR‐371‐373 cluster in the exosomes may mediate this effect by regulating the hepatic differentiation of HPCs.
Liang Ye, Shi Li, Guofang Bi, Binghui Li, Zhai Cai, Meixian Jin, Ying Zhang, Wanren Yang, Yang Li, Shao Li, Wei Hu, Yi Gao, Mingxin Pan, Shuqin Zhou, Chao Zhang, Huichang Bi, Qing Peng   +16 more
wiley   +1 more source

Fully Parallel Turbo Equalization for Wireless Communications

IEEE Access, 2015
Iterative turbo equalization is capable of achieving impressive performance gains over the conventional non-iterative equalization having the same complexity, when communicating over channels that suffer from intersymbol interference (ISI).
Hoang Anh Ngo, Robert G. Maunder, Lajos Hanzo   +2 more
doaj   +1 more source