Results 191 to 200 of about 2,800,552 (286)

Inhibiting Glutaminase Reverses Senescence‐Associated Mitochondrial Dysfunction and Skeletal Muscle Decline

Aging Cell, Volume 25, Issue 10, October 2026.
Pharmacological inhibition of glutaminase with drug CB‐839 restores mitochondrial function in senescent myoblasts and enhances muscle strength and endurance in progeria mice. ABSTRACT Age‐associated loss of skeletal muscle mass and function, also known as sarcopenia, is closely linked to mitochondrial dysfunction.
Hamsa Vardini Senthil Kumar, Debanik Choudhury, Pedro Lei, Pihu Mehrotra, Shahryar Shahini, Sydney Swedick, John Toftegaard, Stelios T. Andreadis   +7 more
wiley   +1 more source

uPAR‐Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non‐Human Primates With Serum Aminotransferase Activity as a Safety Monitor

Aging Cell, Volume 25, Issue 10, October 2026.
GFD‐CD3, a uPAR‐targeting T‐cell engager, effectively cleared senescent cells and mitigated age‐related pathologies with a favorable safety profile under transaminase‐guided monitoring. ABSTRACT Senolytic CAR‐T cells targeting uPAR induce dose‐dependent toxicities.
Jian Deng, Xiaozhu Zeng, Jing Guo, Lihong Li, Shirui Zou, Nan Liu, Shuai He, Lanzhen Yan, Qiong Wang, Yongjie Zhu, Ben Wang, Dong Yang, Longbao Lv, Xudong Zhao   +13 more
wiley   +1 more source

Automated long axial field of view PET image processing and kinetic modelling with the TurBO toolbox. [PDF]

Eur J Nucl Med Mol Imaging
Tuisku J, Palonen S, Kärpijoki H, Latva-Rasku A, Tuomola N, Harju H, Nesterov SV, Oikonen V, Iida H, Teuho J, Han C, Karjalainen T, Kirjavainen AK, Rajader J, Klén R, Nuutila P, Knuuti J, Nummenmaa L.   +17 more
europepmc   +1 more source

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

Two-fraction Ultrahypofractionated Radiotherapy with focal BOost for intermediate-risk, localized prostate cancer (TURBO): study protocol of a phase II, randomized controlled clinical trial. [PDF]

Trials
Lalmahomed TA, Monninkhof EM, van Rijssel MJ, van Melick HHE, Verkooijen HM, de Boer JCJ, van der Voort van Zyp JRN.   +6 more
europepmc   +1 more source

Application of Multi‐Method Dating for Understanding the Gravettian North of Moravia, Central Europe

Archaeometry, Volume 68, Issue 5, Page 1050-1061, October 2026.
ABSTRACT This article presents the results of integrating three methods to assess the age of the Upper Palaeolithic site of Pietraszyn 11 (SW Poland), close to the Moravian Gate. Sediment chronology determined using optically stimulated luminescence produced promising, yet ambiguous results (51.0 ± 3.7 to 20.3 ± 0.7 ka).
A. Wiśniewski, B. Bujalska, D. Popović, M. Baca, K. Zarzecka‐Szubińska, A. Lemanik, M. Hein, S. Talamo, P. Moska, H. Fewlass, D. Tokarz, Z. Jary, B. Przybylski, D. Bobak, M. Połtowicz‐Bobak, K. Wertz, A. Nadachowski   +16 more
wiley   +1 more source

DeepSeek vs ChatGPT vs Claude: benchmarking large language models for clinical diagnosis using a novel ICD-10-CM-based evaluation framework. [PDF]

BMC Med Inform Decis Mak
Du L, Zhong J, Zheng S, Chen L.
europepmc   +1 more source

Inducible tomato defences persist in detached leaves, despite differential plant variety and gene‐dependent expression

Ecological Entomology, Volume 51, Issue 5, Page 866-874, October 2026.
Short‐ and long‐term expression of PPO‐D, PI‐IIc and PR‐1a were assessed in intact plants and detached tomato leaves of two varieties infested with Tetranhycus urticae. Tomato defences were induced in both intact and detached leaves, but the induction levels varied with plant variety and gene assessed.
Mariya Kozak, Diogo P. Godinho, Eren Yayla, Juan Adánez, Inês Fragata, Sara Magalhães, Leonor R. Rodrigues   +6 more
wiley   +1 more source

Developing and Evaluating the Use of ChatGPT as a Screening Tool for Nurses Conducting Structured Literature Reviews: Proof of Concept Study Results

Journal of Clinical Nursing, Volume 35, Issue 10, Page 4009-4021, October 2026.
ABSTRACT Aim To examine the feasibility of using a large language model (LLM) as a screening tool during structured literature reviews to facilitate evidence‐based practice. Design A proof‐of‐concept study. Methods This paper outlines an innovative method of abstract screening using ChatGPT and computer coding for large scale, effective and efficient ...
Alexandra Mudd, Tiffany Conroy, Siri Lygum Voldbjerg, Anita Goldschmied, Rebecca Feo, Lambert Schuwirth   +5 more
wiley   +1 more source

Dynamism and evolvability in nucleic acid enzymes. [PDF]

Nat Commun
Lee EM, Chaput JC.
europepmc   +1 more source