Results 221 to 230 of about 86,909 (315)

Revisiting the Evolution and Function of NIP2 Paralogues in the Rhynchosporium Spp. Complex

open access: yesPlant Pathology, Volume 74, Issue 6, Page 1622-1640, August 2025.
A new long‐read assembly of Rhynchosporium commune reveals ancestral duplication of the Necrosis‐Inducing Protein 2 effector family, which are upregulated during infection but do not cause necrosis on barley. ABSTRACT The fungus Rhynchosporium commune, the causal agent of barley scald disease, contains a paralogous effector gene family called Necrosis ...
Reynaldi Darma   +11 more
wiley   +1 more source

Resistance and Aerobic Preconditioning Delays Unloading‐Induced Multisystemic Physiological Changes: The NEBULA Project

open access: yesThe FASEB Journal, Volume 39, Issue 13, 15 July 2025.
This graphical abstract illustrates the NEBULA project, which examines combined high intensity preconditioning exercise as a countermeasure to microgravity. Mice underwent 3 weeks of training before 7–21 days of hindlimb unloading. After 7 days of simulated microgravity, trained mice showed positive adaptations related to the prevention of ...
Théo Fovet   +18 more
wiley   +1 more source

Translating Muscle RNAseq Into the Clinic for the Diagnosis of Muscle Diseases

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 7, Page 1465-1479, July 2025.
ABSTRACT Objective Approximately half of patients with hereditary myopathies remain without a definitive genetic diagnosis after DNA next‐generation sequencing (NGS). Here, we implemented transcriptome analysis of muscle biopsies as a complementary diagnostic tool for patients with muscle disease but no definitive genetic diagnosis after exome ...
Alba Segarra‐Casas   +24 more
wiley   +1 more source

DCAF16‐Based Covalent Molecular Glues for Targeted Protein Degradation of Histone Deacetylases

open access: yesArchiv der Pharmazie, Volume 358, Issue 7, July 2025.
Inspired by the recently identified vinylsulfonyl piperazine handle, which enables conjugation to protein of interest ligands for targeted protein degradation, a novel class of DCAF16‐based covalent molecular glues to degrade histone deacetylases (HDACs) was developed.
Tao Sun   +6 more
wiley   +1 more source

Conspiracy Beliefs and the Existential Threat of Cancer: A Cross‐Sectional Study in a Sample of Cancer Patients

open access: yesJournal of Community &Applied Social Psychology, Volume 35, Issue 4, July/August 2025.
ABSTRACT Cancer can be regarded as an existential threat, since it evokes profound feelings of fear and uncertainty regarding survival and quality of life. While conspiracy theories tend to thrive in existential threat situations, no research has yet examined the role of these theories in the lives of cancer patients.
Achilleas Piliousis   +3 more
wiley   +1 more source

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