Results 231 to 240 of about 86,909 (315)

IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer

open access: yesClinical and Translational Medicine, Volume 15, Issue 7, July 2025.
The interaction between m6A and APA is mediated by the m6A regulator IGF2BP2 and the APA factor CPSF6 The transcripts harbouring m6A modification tend to use the proximal polyadenylation signal (PAS) in ovarian cancer (OC) PUM2 promotes the malignant progression of OC through its m6A methylation and APA processing .
Xin Luo   +14 more
wiley   +1 more source

A strategy for cost-effective large language model use at health system-scale. [PDF]

open access: yesNPJ Digit Med
Klang E   +11 more
europepmc   +1 more source

Suppression of Plant Resistance May Be a Common Trait Among Adapted Herbivores

open access: yesEcology and Evolution, Volume 15, Issue 7, July 2025.
The intraspecific variation within the spider mites is a model for adaptive pest evolution on crops such as tomato. Here, Tetranychus urticae populations sampled from tomato at three field sites were compared, revealing that suppression is the dominant phenotype in mite strains collected from field‐grown tomatoes.
Jéssica Teodoro‐Paulo   +6 more
wiley   +1 more source

Reproductive Transitions and Sperm Utilisation in a Facultatively Parthenogenetic Stick Insect

open access: yesEcology and Evolution, Volume 15, Issue 7, July 2025.
Facultative parthenogenesis enables females to switch from asexual (parthenogenetic) to sexual reproduction after mating, but the process of fertilisation is poorly understood in such animals. It is unknown whether switching reproductive modes requires changes in the eggs themselves, delaying the transition from laying unfertilised to fertilised eggs ...
Jigmidmaa Boldbaatar   +4 more
wiley   +1 more source

ADAM Sheddase Activity Promotes the Detachment of Small Extracellular Vesicles From the Plasma Membrane

open access: yesJournal of Extracellular Vesicles, Volume 14, Issue 7, July 2025.
ABSTRACT Small extracellular vesicles (SEVs) are involved in diverse functions in normal and pathological situations, including intercellular communication, immunity, metastasis and neurodegeneration. Cell release of SEVs is assumed to occur passively right after multivesicular bodies of the endocytic pathway fuse with the plasma membrane. We show here
Chloé Bizingre   +12 more
wiley   +1 more source

Eco‐Friendly, Sound Absorbing Materials Based on Cellulose Acetate Electrospun Fibers/Luffa Cylindrica Composites

open access: yesMacromolecular Rapid Communications, Volume 46, Issue 13, July 04, 2025.
A 3D natural sponge named Luffa Cylindrica (LC) and cellulose acetate (CA) microfibrous layers fabricated through electrospinning are combined in various configurations, showing potential as innovative, eco‐friendly solutions for sound absorption applications.
Viktoria Theodorou   +5 more
wiley   +1 more source

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